RESUMO
In the current analysis of classic conditioning with regard to the phenomenon of drug tolerance, there is empirical evidence of interoceptive pharmacologic cues and of exteroceptive cues, which are associated with the effect of the drug. The former could overshadow the latter. The aim of the present investigation was to contribute experimental data about the interaction that occurs between these two kinds of cues. For this purpose, a set of interoceptive and exteroceptive cues was presented as conditioned stimulus, together with an unconditioned stimulus that corresponded to the ataxic effects of ethanol. The results showed that the interoceptive cues were associated with the ataxic effect of ethanol, and they produced a tolerance response of the same intensity as the exteroceptive cues.
Assuntos
Ataxia/induzido quimicamente , Depressores do Sistema Nervoso Central/efeitos adversos , Tolerância a Medicamentos , Etanol/efeitos adversos , Animais , Masculino , Ratos , Ratos Sprague-DawleyRESUMO
En el análisis actual del condicionamiento clásico frente al fenómeno de la tolerancia a las drogas existe evidencia empírica de que las claves farmacológicas interoceptivas, al igual que las claves exteroceptivas, se asocian con los efectos de la droga y que las primeras pueden llegar a ensombrecer a las segundas. El propósito de esta investigación es aportar datos experimentales sobre la interacción que se da entre ambos tipos de claves, para ello se presentó como estímulo condicionado un compuesto de claves interoceptivas y exteroceptivas junto al estímulo incondicionado correspondiente a los efectos atáxicos del etanol. Los resultados demostraron que las claves interoceptivas se asociaron con el efecto atáxico del etanol, y éstas presentaron una respuesta de tolerancia de la misma intensidad que la de las claves exteroceptivas
In the current analysis of classic conditioning with regard to the phenomenon of drug tolerance, there is empirical evidence of interoceptive pharmacologic cues and of exteroceptive cues, which are associated with the effect of the drug. The former could overshadow the latter. The aim of the present investigation was to contribute experimental data about the interaction that occurs between these two kinds of cues. For this purpose, a set of interoceptive and exteroceptive cues was presented as conditioned stimulus, together with an unconditioned stimulus that corresponded to the ataxic effects of ethanol. The results showed that the interoceptive cues were associated with the ataxic effect of ethanol, and they produced a tolerance response of the same intensity as the exteroceptive cues
