Cáncer de vulva en la mujer joven no asociado a infección por virus del papiloma humano: a propósito de un caso / Vulvar cancer in young women not associated with human papilloma virus infection: A propos of a case

El cáncer de vulva supone el 5% de todos los cánceres ginecológicos. Es la 4.ª causa de neoplasia del tracto genital femenino más frecuente tras la de endometrio, cérvix y ovario. El 90% de los cánceres vulvares son escamosos. Su etiología, en general, se desconoce, pero existen pruebas que categorizan por preferencia el virus del papiloma humano (VPH) como un factor causal de los carcinomas del tracto genital. Otros factores implicados son el tabaco, los tratamientos inmunosupresores, haber padecido cáncer de cervix y las neoplasias vulvares intraepiteliales (VIN). A continuación presentamos el caso de un cáncer clínico de vulva en una mujer de 35 años no asociado a VPH

Vulvar cancer encompasses 5% of all gynecologic cancers. It is the fourth most common cause of female genital tract malignancy after cancer of the endometrium, cervix and ovary. Ninety percent of vulvar cancers are squamous. In general, their etiology is unknown, but there are tests that indicate that human papilloma virus (HPV) is a causal factor in carcinomas of the genital tract. Other implicated factors are smoking, immunosuppressive therapy, prior cancer of the cervix, and vulvar intraepithelial neoplasia (VIN). We present a case of vulvar cancer in a 35-year-old woman not associated with HPV

Current opinion in cervix carcinoma

We review the current status of the conventional therapeutical approaches of cervix carcinoma. Radical hysterectomy remains as the main stone in early stages and play an important role in relapses. Radiotherapy plays an important role in early and advance disease. New techniques and image expand indications and treatment possibilities. Chemotherapy platinum based with radiation therapy goes on being the standard treatment in advanced tumours or non surgical candidates. New systemic strategies are being explored in clinical trials (AU)

Beta-Talasemia mayor y gestación / Beta-Thalasemia major and pregnancy

La mejora en el manejo hematológico, la introducción de la terapia quelante y el avance en las técnicas de reproducción ha hecho que el embarazo en pacientes con betatalasemia mayor sea una realidad y que suponga un reto para los profesionales de la salud, por su enfoque multidisciplinar. Presentamos el caso de una paciente diagnosticada de betatalasemia mayor, con gestación espontánea y buen resultado tanto perinatal como materno, realizando un examen crítico y exhaustivo de la conducta seguida hasta el parto y el puerperio inmediato

Due to improvements in haematological care, the introduction of chelation therapy and the advances in reproductive techniques, pregnancy among patients with Beta-thalassaemia major is not only a reality but also a challenge for health professionals on account of its multidisciplinary approach. We report the case of a patient with Beta-thalassaemia major, with spontaneous pregnancy and a correct maternal and perinatal result, by presenting a comprehensive and critical examination of the procedures followed throughout pregnancy, delivery and the immediate puerperium