RESUMO
Insulin-like growth factor-1 (IGF-1) plays an important role in cell proliferation and differentiation. It actively participates during odontogenesis and mineralization of dental hard tissues. The purpose of this study is to use a radioimmunoassay (RIA) to determine whether there are differences in the expression of IGF-1 in human pulp from teeth having incomplete or complete root development. Twenty-six pulp samples were obtained from freshly extracted human third molars, half of them from teeth with incomplete root development. All of the samples were processed and labeled using an IGF-1 RIA kit. Results showed IGF-1 presence in all human pulp samples with a statistically significant higher expression in pulps having complete root development. The present findings are consistent with the hypothesis that IGF-1 contributes toward forming and mineralizing dental tissues in teeth with incomplete root development as well as in pulp-repairing process in teeth with complete root development.
Assuntos
Polpa Dentária/metabolismo , Fator de Crescimento Insulin-Like I/biossíntese , Raiz Dentária/crescimento & desenvolvimento , Humanos , Dente SerotinoRESUMO
En el presente estudio se evaluó la respuesta clínica e histológica de la utilización de barreras físicas de politetrafuloretileno (Membraflex) para el tratamiento de lesiones de furca grado II creados quirúrgicamente y con enfermedad periodontal inducida. El estudio se realizó en los primeros molares inferiores bilaterales de tres perros criollos colombianos. En estos molares se crearon defectos de furca grado II que posteriormente fueron tratados con raspaje y alisado radicular a campo abierto en el lado control, mientras que en elado experimental se realizó raspaje, alisado radicular y colocación de membranas Membraflex (Laboratorio de Investigación, Productos Orales Ltda., Santafé de Bogotá, D.C., Colombia)
