[Isolated tumor of the rectum as primary manifestation of Burkitt lymphoma (author's transl)]. / Isolierter Rektumtumor als Primärmanifestation eines Burkitt-Lymphoms.

Burkitt tumors are malignant lymphoblastic lymphomas occurring predominantly in Africa in children and young adults and involving in many cases the intestinal tract; these tumors occur rather seldom outside Africa. A case report is given of a white 21 old female suffering from this disease; that first manifestation was an isolated ulcerating tumor of the rectum without involvement of other organs of lymph nodes. Diagnosis was confirmed by rectum biopsy. X-ray therapy, cytostatic therapy and amputation of the rectum did not prevent a fast progression of the disease and final death, which is the usual course of the disease when it occurs outside Africa.

[Carcinoma of the apocrine glands of the vulva with intraepidermal spreading under the picture of invasive Paget's disease (author's transl)]. / Karzinom der apokrinen vulvadrüsen mit vorwiegend epidermaler Ausbreitung unter dem Bilde des invasiv wachsenden Morbus Paget.

The histological findings of Paget's disease of the nipple and of extramammary localisation are well known. The relationship to the so called "adnexal carcinoma" has not become clear to this moment. We report a case of combination of invasive vulva Paget's disease and adnexal carcinoma of the apocrine vulvar glands. Our findings are discussed with the statements of literature about aetiology and pathogenes.

[Experimentally induced heart muscle fiber necroses after premedication with strophanthin (author's transl)]. / Experimentell induzierte Herzmuskelfasernekrosen nach Praemedikation mit Strophanthin

Number and degree of angiotensin-induced heart muscle necrosis in the rat (75 mg/kg body weight) are diminuished by premedication with strophanthin (2 X 10(-2) MG/KG BODY WEIGHT). The electron-microscopic findings are also changed: the application of angiotensin only results in vacuolization of mitochondria and a dilatation of theendoplasmatic reticulum while myofibrils are unaltered. Angiotensin in combination with strophanthin has a direct destructive effect on the myofibrils without evident changes of the mitochondria and tubular system of the heart. The protective action of Strophanithin on the heart muscle cell is discussed in the sense of an exonomization of the cellular metabolism under conditions of relative coronary insufficiency, induced by the vasoconstructive effect of angiotensin.

[Panarteritis nodosa-Special aspects of glucocorticoid and immune suppressive therapy (author's transl)]. / Panarteriitis nodosa. Therapie mit Glukokortikoiden und Immunsuppressiva

Report dealing with the clinical and pathoanatomical course as well as the autopsy findings in a 54 year old female suffering from panarteritis nodosa. Onset of the illness with polyneuritis and arthralgia. One year later diagnosis of panarteritis nodosa verified by muscle biopsy. Deterioration of the disease leading to the development of peripheral gangrene could not be prevented in spite of intensive therapy with steroids, immune suppressive agents, digitalis and antihypertensive drugs. Death 4 years later by myocardial infarction. Autopsy revealed generalized healed panarteritis nodosa with scarring and obliteration of vessels. A short description of the symptoms of the disease is given and the efficacy of the therapy with steroids and immune suppressive drugs is discussed from the clinical as well as the pathoanatomical point of view. Immunopathologic mechanisms are considered to be the responsible factors for pathogenesis.

A contribution to the knowledge of the so-called pyloric band ("double pylorus").

Two new cases of patients with so called muscular pyloric band ("double pylorus") are reported. Both possible genetic mechanisms of this malformation are discussed in detail: primary or congenital, and secondary or acquired by inflammation. After analysis of the hitherto related cases, the opinion is expressed that the so called pyloric band represents a congenital malformation. According to the authors, the striking frequency of simultaneous occurrence of pyloric band and ulcers does not necessarily favour the theory of inflammatory genesis. The accompanying ulcer seems rather to be a "second disease" in the sense of Rossle (1913), manifesting itself at a locus minoris resistentiae.