RESUMO
PURPOSE: This study aims to compare protocol adherence, neurological outcome and adverse effects associated with a controlled hypothermia versus a controlled normothermia protocol in patients successfully resuscitated after cardiac arrest. METHODS: In this retrospective single-center study in a university intensive care unit in Switzerland, post-cardiac arrest patients were compared before and after a protocol change from targeted temperature management at 33⯰C (TTM-33) to 36⯰C (TTM-36) using an intravascular cooling device. Protocol adherence was assessed as the primary outcome. Secondary outcomes were in-hospital mortality, neurological outcome and adverse effects. RESULTS: 373 patients after cardiac arrest were screened, of whom a total of 133 patients were included. Protocol adherence was lower in the TTM-33 group (47% vs 87% of patients, pâ¯<â¯0.01). In-hospital mortality (59% vs 45%, pâ¯=â¯0.15) and neurological outcome (modified Rankin Scoreâ¯<â¯4 in 33% vs 39% and CPC-Scoreâ¯<â¯3 in 33% vs 39% of patients, pâ¯=â¯0.60 and 0.97) were similar. Overall incidence of adverse effects was comparable, with bradycardic arrhythmias occurring more frequently in the TTM-33 group. CONCLUSION: Protocol adherence was higher in the TTM-36 group. In-hospital mortality and neurological outcome were similar, while bradycardic arrhythmias were encountered more often in TTM-33.