1.
Org Lett
; 14(16): 4254-7, 2012 Aug 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22852800
RESUMO
An efficient one pot asymmetric synthesis of tetrahydropyrano[2,3-c]pyrazoles has been developed. This class of biologically active heterocycles can be obtained via a secondary amine catalyzed asymmetric Michael/Wittig/oxa-Michael reaction sequence. Remarkably, the title compounds were accessible in good to very good yields and very good to excellent enantioselectivities after a single purification step.