Assuntos
Síndrome de Birt-Hogg-Dubé/diagnóstico , Síndrome de Birt-Hogg-Dubé/genética , Dermatoses Faciais/diagnóstico , Proteínas Proto-Oncogênicas/genética , Proteínas Supressoras de Tumor/genética , Adulto , Síndrome de Birt-Hogg-Dubé/patologia , Doença Crônica , Cistos/tratamento farmacológico , Dermatoses Faciais/patologia , Humanos , Pneumopatias/diagnóstico por imagem , Masculino , Pescoço , Tomografia Computadorizada por Raios XRESUMO
Tungiasis is a cutaneous parasitosis caused by infestation of the skin by gravid fleas of the genus Tunga, mainly Tunga penetrans. This flea is very common in tropical and subtropical regions of the globe, but not in Europe. The infestation is acquired by walking barefoot or lying in places where the flea is present, usually beaches or sandy soils. We report two unrelated cases of imported tungiasis in Portugal that presented to our clinic in the same week. We draw attention to one of the most common dermatological diseases in travelers returning from tropical countries, the diagnosis of which is primarily clinical but nonetheless is largely unfamiliar to clinicians attending those patients.
Assuntos
Doenças do Pé/diagnóstico , Doenças do Pé/parasitologia , Viagem , Tungíase/diagnóstico , África , Animais , Brasil , Dermoscopia , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Portugal , Tunga , Tungíase/parasitologiaAssuntos
Ácido Aminolevulínico/análogos & derivados , Coloides , Dermatoses Faciais/tratamento farmacológico , Fotoquimioterapia/métodos , Dermatopatias/tratamento farmacológico , Ácido Aminolevulínico/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Fármacos Fotossensibilizantes/uso terapêuticoRESUMO
Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis. We describe a 62-year-old man presenting a 2-month history of firm nodular lesions on the upper lip. Histopathology, immunohistochemical, and ultrastructural analysis showed typical findings of ICH. The patient was treated with thalidomide and almost complete regression of the lesions was reached within 7 months. Nevertheless, one month after remission, he developed an acute myeloid leukemia of the subtype monocytic leukemia (M5). The patient's condition rapidly worsened and he died due to a respiratory failure four weeks later. We present this case because apart of being rare it joins the effectiveness of thalidomide and the association with an acute monocytic leukemia. A review of the literature is made.
