Clinical diagnostic performance of common laboratory indicators in primary glomerulonephritis.

OBJECTIVE: Immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) are common types of primary glomerulonephritis (PGD). A lack of specific clinical features makes diagnosis difficult. Kidney function indicators have been used for their diagnosis. However, the diagnostic performance of these indicators is undetermined. The purpose of this paper is to evaluate their diagnostic potential. PATIENTS AND METHODS: 101 patients with PGD were enrolled, including 50 with MN and 51 with IgAN. The healthy controls included 110 volunteers. The indicators related to kidney function, including TP, ALB, Cre, CysC, eGFR, C1q, Ure, Anti-PLA2R, complement C3, and complement C4 in serum, ACR in urine, and antinuclear antibody profile, IgG staining, IgA staining, IgM staining, C3 staining and C1q staining in tissue samples were evaluated. RESULTS: Statistical differences were found in TP, ALB, Ure, CysC, eGFR, C1q, Anti-PLA2R, complement C3, complement C4 and ACR among the three groups of subjects. ROC analysis showed that Anti-PLA2R and ACR had the highest specificity for identifying IgAN and/or MN from the healthy controls, ACR had the highest sensitivity. The Sp and Se of IgA and IgG in tissue samples for the identification of IgAN and MN were both high. Both IgAN and MN were predicted by anti-PLA2R, especially MN. In tissue samples, MN patients were more likely to be IgG positive and IgAN patients were more likely to be IgA positive. CONCLUSIONS: IgAN and MN may be differentiated using serum Anti-PLA2R, tissue IgG, and tissue IgA. Cre is only useful in middle and late stages of GPDs, ACR is an exclusion marker, and CysC and C1q cannot be used to identify MN.

Controlled state transfer in a Heisenberg spin chain by periodic drives.

The spin chain is a system that has been widely studied for its quantum phase transition. It also holds potential for practical application in quantum information, including quantum communication and quantum computation. In this paper, we propose a scheme for conditional state transfer in a Heisenberg XXZ spin chain. In our scheme, the absence or presence of a periodic driving potential results in either a perfect state transfer between the input and output ports, or a complete blockade at the input port. This scheme is formalized by deriving an analytical expression of the effective Hamiltonian for the spin chain subject to a periodic driving field in the high-frequency limit. The influence of the derivation of the optimal parameter on the performance of the state transfer is also examined, showing the robustness of the spin chain for state transfer. In addition, the collective decoherence effect on the fidelity of state transfer is discussed. The proposed scheme paves the way for the realization of integrated quantum logic elements, and may find application in quantum information processing.

Optically tunable spin texture of the surface state for Bi2Se3 and SmB6 topological insulators.

The spin texture of the surface state for topological insulators can be manipulated by the polarization of light, which might play a potential role in the applications in spintronics. However, the study so far in this direction mainly focuses on the classical light-topological-insulators interactions; TIs coupled to quantized light remains barely explored. In this paper, we develop a formalism to deal with this issue of spin texture of the surface state for topological insulators (for example Bi2Se3 and SmB6) irradiated by a quantum field, and we find that the coupling between an electron and a single-mode quantum field modulates only the arrow length that represents the spin polarization of a topological surface state. Specifically, when the photon number of a single-mode quantum field is fixed, the azimuth angle between the quantum light and the material surface manipulates the spin textures along the constant energy contour rotating (clockwise or counterclockwise) around the high symmetry point, and the polar angle controls the magnitude of the spin polarization. These results are quite different from the situation where an external field is not applied to an electron in a crystal or where a classical external field is utilized to control the spin polarization of a photoemitted electron in a vacuum. Our results have potential applications in quantum optics and condensed-matter physics.

A preliminary study on the occurrence and behavior of carbamazepine (CBZ) in aquatic environment of Yangtze River Delta, China.

The occurrence and behavior of carbamazepine (CBZ) was investigated in aquatic environment of Yangtze River Delta, East China. The water samples were enriched by solid-phase extraction and analyzed by high-performance liquid chromatography with diode array detector. The validation of the analytical method included linearity (0.1-1 mg/L), recovery studies, and determination of limits of quantification. Limits of quantification of CBZ in various aquatic samples were in the range of 0.1-0.2 µg/L. CBZ was detected in the Tongji University Intramural River, the Huangpu River, and the Suzhou River with the highest concentration of 1,090 ng/L, but not detected in the Nanhengyin River and the Caojia River. In sewage water samples, CBZ was not detected in one of the sewage treatment plants (STPs) but was detected in the raw influents and effluents at the other three selected STPs in Shanghai, with the concentrations ranging from 230 to 1,110 ng/L. CBZ was not completely eliminated after secondary treatment (with the active sludge process).

Effect of emodin on Candida albicans growth investigated by microcalorimetry combined with chemometric analysis.

Using the 3114/3115 thermal activity monitor (TAM) air isothermal microcalorimeter, ampoule mode, the heat output of Candida albicans growth at 37 degrees C was measured, and the effect of emodin on C. albicans growth was evaluated by microcalorimetry coupled with chemometric methods. The similarities between the heat flow power (HFP)-time curves of C. albicans growth affected by different concentrations of emodin were calculated by similarity analysis (SA). In the correspondence analysis (CA) diagram of eight quantitative parameters taken from the HFP-time curves, it could be deduced that emodin had definite dose-effect relationship as the distance between different concentrations of it increased along with the dosage and the effect. From the principal component analysis (PCA) on eight quantitative parameters, the action of emodin on C. albicans growth could be easily evaluated by analyzing the change of values of the main two parameters, growth rate constant k (2) and maximum power output P(2)(m). The coherent results of SA, CA, and PCA showed that emodin at different concentrations had different effects on C. albicans growth metabolism: A low concentration (0-10 microg ml(-1)) poorly inhibited the growth of C. albicans, and a high concentration (15-35 microg ml(-1)) could notably inhibit growth of this fungus. This work provided a useful idea of the combination of microcalorimetry and chemometric analysis for investigating the effect of drug and other compounds on microbes.

Treatment of succinonitrile wastewater by immobilized high efficiency microorganism strains.

Using succinonitrile as a sole source of carbon and nitrogen, two bacterium strains named as J-1-3 and J-13-1 were isolated and screened out from the treatment facilities of Shanghai petrochemical wastewater treatment plant treating acrylic fiber production wastewater. The optimal growth conditions of the two strains in the degradation of succinonitrile with varied initial concentrations were determined through flask tests as follows: temperature 30 degrees C, shaker rotary speed of 250 r/min, inoculum percentage 0.1%, and initial pH 6. Results indicate that the two strains, especially J-13-1, exhibited a high efficiency for succinonitrile degradation. Thereafter, the bacterium strains were immobilized separately by sodium alginate and polyvinyl alcohol 1750 +/- 50, and applied to succinonitrile degradation again. Results show that in a very broad range of the initial succinonitrile concentration, i.e., 30-5,000 mg/L, the sodium alginate immobilized grains could degrade more than 80% of succinonitrile after 24 h under the experimental conditions of 30 degrees C, pH 6.5, and shaker rotary speed of 250 r/min. However, the polyvinyl alcohol immobilized grains tended to inflate and break down due to a weak mechanical strength.