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1.
Commun Biol ; 4(1): 671, 2021 06 03.
Artigo em Inglês | MEDLINE | ID: mdl-34083720

RESUMO

Wolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although several herbaceous species of Solanaceae have been subjected to genome sequencing, thus far, no genome sequences of woody representatives have been available. Here, we sequenced the genomes of 13 perennial woody species of Lycium, with a focus on Lycium barbarum. Integration with other genomes provides clear evidence supporting a whole-genome triplication (WGT) event shared by all hitherto sequenced solanaceous plants, which occurred shortly after the divergence of Solanaceae and Convolvulaceae. We identified new gene families and gene family expansions and contractions that first appeared in Solanaceae. Based on the identification of self-incompatibility related-gene families, we inferred that hybridization hotspots are enriched for genes that might be functioning in gametophytic self-incompatibility pathways in wolfberry. Extremely low expression of LOCULE NUBER (LC) and COLORLESS NON-RIPENING (CNR) orthologous genes during Lycium fruit development and ripening processes suggests functional diversification of these two genes between Lycium and tomato. The existence of additional flowering locus C-like MADS-box genes might correlate with the perennial flowering cycle of Lycium. Differential gene expression involved in the lignin biosynthetic pathway between Lycium and tomato likely illustrates woody and herbaceous differentiation. We also provide evidence that Lycium migrated from Africa into Asia, and subsequently from Asia into North America. Our results provide functional insights into Solanaceae origins, evolution and diversification.


Assuntos
Cromossomos de Plantas/genética , Genoma de Planta/genética , Lycium/genética , Solanaceae/genética , Sequenciamento Completo do Genoma/métodos , África , Ásia , Evolução Molecular , Frutas/genética , Frutas/metabolismo , Regulação da Expressão Gênica de Plantas , Geografia , Lycium/classificação , Lycium/metabolismo , América do Norte , Filogenia , Poliploidia , Polissacarídeos/metabolismo , Solanaceae/classificação , Solanaceae/metabolismo , Especificidade da Espécie
2.
Org Lett ; 21(7): 2269-2272, 2019 04 05.
Artigo em Inglês | MEDLINE | ID: mdl-30908054

RESUMO

A novel, efficient Z-alkene synthesis via photocatalyzed decarboxylative couplings between terminal aryl alkynes and alkyl N-hydroxyphthalimide (NHPI) esters, which are derived from aliphatic carboxylic acids, is described. A wide range of primary, secondary, and tertiary carboxylates as well as α-amino acid and α-oxyacid-derived esters were employed as suitable substrates. The mild reaction conditions, broad substrate scope, functional group tolerance, and operational simplicity make this decarboxylative coupling reaction a valuable method in organic syntheses.

3.
J Org Chem ; 83(12): 6762-6768, 2018 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-29768006

RESUMO

Efficient syntheses of 3,3-difluorooxindoles and 3-fluorooxindoles via fluorination of hydrazonoindolin-2-one with Selectfluor are reported. Under different solvent conditions, this method produced 3,3-difluorooxindoles and 3-fluorooxindoles selectively. The broad substrate scope and mild reaction conditions make this transformation a valuable method in drug discovery and development.

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