Frequency of MED12 Mutation in Relation to Tumor and Patient's Clinical Characteristics: a Meta-analysis.

Mediator complex subunit 12 (MED12) is the most frequently mutated gene in uterine leiomyomas (ULs)-with a frequency of up to 85%-suggesting that it plays key roles in the pathogenesis of ULs. However, there is no established relationship between genetic alteration and other risk factors of UL pathogenesis such as the patient's age, weight, and race. In this meta-analysis, we established an association between these risk factors and the frequency of MED12 mutation. We also established the relationship between MED12 mutation with the number and size of tumors in a patient. A systematic literature search was performed for studies published by May 2020 and performed a meta-analysis according to PRISMA guidelines. Twenty-five studies were included in the analysis, representing 3151 tissue samples. MED12 mutations were more common in Black (74.5%) as compared to White (65.8%) and Asian (53.2%) patients. There was no significant relationship between the patient's age and the frequency of mutations (OR 0.73, 95% CI 0.38 to 1.41). MED12 mutations were common in patients barring small-sized (OR 1.46, 95% CI 1.09 to 1.95) multiple (OR 0.39, 95% CI 0.17 to 0.92) tumors. For the patient's weight, studies were few and the outcome was not statistically significant. This meta-analysis provides valuable information on the relationship between the patient's clinical characteristics and frequency of MED12 mutation among patients barring ULs, which is relevant for understanding the pathogenesis of ULs.Protocol registration: The protocol was registered in PROSPERO with registration number CRD42019123439.

Substituent group-tunable hydrogen evolution activity observed in isostructural Cu(ii)-based coordination polymer photocatalysts.

Elucidations on the structure-activity correlations of non-Pt coordination polymer (CP)-based photocatalysts are highly significant for both the enhancement in catalytic activity and large-scale industrial applications of sustainable hydrogen from water splitting. Herein, three isostructural [Cu(HL)2(R-BDC)]n (denoted as Cu-CP-R, HL = 4'-(4-hydroxyphenyl)-4,2':6',4''-terpyridine, R-BDC = 2-R-1,4-benzenedicarboxylate, R = NO2, OH and Br) CPs were solvothermally synthesized by varying the substituents attached to benzenedicarboxylate, which together with two previously reported analogues (R = NH2 and H) were used as photocatalysts to systematically explore the substitution effect on the hydrogen evolution activity. These five CPs feature isomorphic layered motifs with axially elongated CuII octahedra extended alternately by ditopic HL and R-BDC2- connectors, in which R behaves structurally as a non-coordinate group. The hydrogen production rate over the Cu-CP-R photocatalysts increased from 0.21 to 2.34 mmol g-1 h-1, which followed the order of -NH2 > -NO2 > -H > -OH > -Br. Furthermore, the combined experimental and theoretical investigations reveal that the free R moiety significantly dominates the photocatalytic activity by shifting the d states of the CuII ion towards the Fermi level, controlling the potential of the conduction band and quickening the charge transfer ability. These important findings can provide informative hints for the design of high-performance, earth-abundant non-noble metal CP-based semi-conductive photocatalysts.