Angiotensin converting enzyme inhibitors induced acute kidney injury in newborn.

Angiotensin converting enzyme inhibitors (ACEI) are known to cause fetopathies and acute kidney injury (AKI) in neonates. It is important to monitor neonates on ACEI to prevent severe rebound hypotension as well as an acute renal impairment or failure.

Early versus late inguinal hernia repair in extremely low-birthweight infants.

OBJECTIVE: Compare outcomes of extremely low-birthweight (ELBW) infants following early (before discharge) versus late (after discharge) inguinal hernia (IH) repair. STUDY DESIGN: In a retrospective study of ELBW infants with IH, data were abstracted for clinical characteristics, IH and related outcomes. RESULT: Of the 39/252 (15.4%) ELBW infants who developed IH, those with early (59%) versus late (41%) repair were comparable in birth weight (753 ± 158 versus 744 ± 131 g, p = 0.84), gestation age (26 ± 2 versus 26.2 ± 2 weeks, p = 0.92), with comparable rate of broncopulmonary dysplasia (87% versus 75%, p = 0.41), but early repair group had prolonged respiratory support (60.6 ± 28.6 versus 39 ± 30 days, p = 0.032). Both groups had comparable diagnosis to repair interval (51.2 ± 29.2 versus 60.5 ± 30.6 days, p = 0.38) and early repair group has earlier corrected gestation (41.6 ± 3.9 versus 45.4 ± 4.6 weeks, p < 0.01) at time of repair. Post-IH repair complications (incarceration, postoperative apnea, infections, recurrence and testicular atrophy) were not different. CONCLUSIONS: We did not find significant differences in outcomes of IH in early and late repair groups of ELBW infants.