1.
Org Lett
; 3(15): 2313-6, 2001 Jul 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11463304
RESUMO
[structure: see text] The design, synthesis, and enzyme inhibition of a new class of aspartic peptidase inhibitors is described. Unsymmetrical ureas were designed from computer-generated structures. Using mechanism-based and substrate-based design techniques, potent pepsin inhibitors were developed and the binding mode was established. Two X-ray crystal structures of enzyme-bound inhibitors revealed a new binding mode that is closely related to the computer-generated binding mode.