1.
Org Lett
; 3(24): 3943-6, 2001 Nov 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11720575
RESUMO
The highly diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide is reported. Homoallylamines with high enantiomeric purity are obtained from the adducts in three steps on removal of the chiral auxiliary by means of a nonreductive protocol. Removal of the auxiliary by hydrogenation leads to the saturated amines, also in high enantiomeric purity. [reaction: see text]