An unusual ring contraction in the formation of N-nitrosohexamethyleneimine and N-nitrosopiperidine from tolazamide.

The previously reported reaction of tolazamide with nitrite, under physiological conditions, to form N-nitrosohexamethyleneimine and surprisingly, N-nitrosopiperidine was confirmed. By using the six-membered ring analogue of tolazamide, 1-(piperidyl)-3-(p-tolylsulfonyl)urea, which yields the corresponding N-nitrosopiperidine and N-nitrosopyrrolidine, the present study shows that an unusual ring contraction occurs, excising the carbon alpha to the nitrogen.

Turnover benefits: the other side of the "costs" coin.

High levels of turnover have traditionally been viewed by human resources managers as having a negative effect on the organization. But the authors--Idalene F. Kesner, associate instructor in business policy, and Dan R. Dalton, assistant professor of administrative and behavioral studies, both at the Graduate School of Business, Indiana University--maintain that responsible levels of employee turnover may have both direct and indirect benefits for the organization. Such benefits include displacement of poor performers, an infusion of new knowledge in the organization, and the stimulation of changes in policies and practices. In addition, of course, there are opportunities for cost reduction and consolidation. Using data compiled from the experience of a California public utility, the authors show how to calculate the direct, hard-dollar value of the savings that can be realized in regular pay, overtime pay, pension contributions, earned but unused sick leave, and other areas.

Technical problems associated with the production of technetium Tc 99m tin(II) pyrophosphate kits.

The amount of tin(II) required for adequate reduction, complexation, and stability of technetium Tc 99m pertechnetate in radiopharmaceutical kits, and methods of preventing the loss of tin(II) during formulation of these lyophilized kits are investigated. Tin(II) loss from stannous chloride solutions was studied under several conditions, including room air versus nitrogen atmospheres, during vial filling in a laminar-flow hood with samples frozen on dry ice versus samples at room temperature, during lyophilization, and during storage under refrigerated, ambient, and elevated temperatures. Various amounts of stannous chloride, ranging from 5 to 1000 microgram/ml, were used in formulating sodium pertechnetate Tc 99m kits containing 100 mCi technetium Tc 99m and 0.4 microgram total technetium. Samples were removed at various times; hydrolyzed technetium, pertechnetate, and technetium Tc 99m pyrophosphate were isolated on instant thin-layer chromatography-silica gel and quantified with a scintillation counter. The time necessary to deoxygenate distilled water by nitrogen purging was measured. Several sources of stannous chloride were assayed for tin(II) content. Tin(II) loss occurs rapidly in solution (15% in one hour) unless continuously protected with nitrogen, and during vial filling in a laminar-flow hood unless frozen with dry ice. No substantial loss of tin(II) was detected during lyophilization or during storage of lyophilized product at any of the three temperatures. A minimum of 400 microgram tin(II) was required to provide 90% technetium Tc 99m pyrophosphate at six hours after preparation. Adequate deoxygenation of small quantities (450 ml) of water was accomplished in less than one hour. Some stannous chloride salts were highly oxidized in the dry state, and only high-purity elemental tin wire gave acceptable yields of tin(II).

Win, loss, draw: the grievance process in practice.

The grievance procedure can be a very expensive proposition. Here's a listing of the most commonly filed grievances and what to expect when you're confronted by them.

Turnover turned over: an expanded and positive perspective.

The negative impact of turnover is well documented in the literature. This paper examines turnover with a unique, positive focus. Turnover is reviewed, not only from the standpoint of the organizational theorist, but with economic, sociological, and psychological/social psychological perspectives. Often ignored benefits of turnover are noted.

A simple device for efficient transfer and unit dose packaging of Xe-127: concise communication.

An inexpensive system has been devised for the efficient transfer of Xe-127 gas from the manufacturer's ampule into individual dose vials for patient use. By displacing the gas with an aqueous solution, the initial transfer is made from an ampule of known activity into an evacuated serum vial of predetermined volume with transfer efficiency greater than 99%. A similar principle is used to transfer Xe-127 from the stock serum vial into individual dose vials, with total xenon recovery exceeding 98%. Ability to deliver the desired activity to each vial is within 90-110% of that predicted by calculation. Reproducibility in delivering a given activity was excellent, with all vials falling between 95 and 105% of the mean activity. Stability studies showed that 94% of the Xe-127 activity can be removed from the vials with only 6% absorbed in the rubber stopper after 5 wk of storage. The device costs less than $25.00 and can be constructed easily from common laboratory materials.