Simultaneous spectrophotometric determination of drotaverine hydrochloride and paracetamol in tablet.

Two simple, accurate and reproducible spectrophotometric methods; Q analysis and first order derivative method have been described for the simultaneous estimation of drotaverine hydrochloride and paracetamol in combined tablet dosage form. Absorption maxima of drotaverine hydrochloride and paracetamol in distilled water were found to be 303.5 nm and 243.5 nm respectively. Beer's law was obeyed in the concentration range 5-50 mug/ml for drotaverine and 5-60 mug/ml for paracetamol. In Q analysis method, two wavelengths were selected at isobestic point (277 nm) and lambda(max) of paracetamol (243.5 nm). In first order derivative method, zero crossing point for drotaverine hydrochloride and paracetamol were selected at 303.5 nm and 243.5 nm, respectively. The results of two methods were validated statistically and recovery studies were found to be satisfactory.

Glycaemic index of some commonly consumed foods in western India.

Glycaemic index (GI) was determined in 36 non-insulin-dependent diabetes mellitus (NIDDM) patients. The subjects were fed 50g carbohydrate portions of six foods consumed widely in India including Varagu (Plaspalum scorbiculatum) alone and in combination with whole and dehusked greengram (Phaseolus aureus Roxb), Bajra (Penniseteum typhoideum), Jowar (Sorghum vulgare) and Ragi (Eleusine coracana). The GI of Varagu alone, Varagu in combination with whole greengram and Bajra was significantly lower than that of Ragi which produced a glycaemic response equivalent to that of the glucose load.