Electrospun PAN/PEG Nanofibrous Membrane Embedded with a MgO/gC3N4 Nanocomposite for Effective Bone Regeneration.

Developing biomaterial scaffolds using tissue engineering with physical and chemical surface modification processes can improve the bioactivity and biocompatibility of the materials. The appropriate substrate and site for cell attachment are crucial in cell behavior and biological activities. Therefore, the study aims to develop a conventional electrospun nanofibrous biomaterial using reproducible surface topography, which offers beneficial effects on the cell activities of bone cells. The bioactive MgO/gC3N4 was incorporated on PAN/PEG and fabricated into a nanofibrous membrane using electrospinning. The nanocomposite uniformly distributed on the PAN/PEG nanofiber helps to increase the number of induced pores and reduce the hydrophobicity of PAN. The physiochemical characterization of prepared nanoparticles and nanofibers was carried out using FTIR, X-ray diffraction (XRD), thermogravimetry analysis (TGA), X-ray photoelectron spectroscopy (XPS), and water contact angle measurements. SEM and TEM analyses examined the nanofibrous morphology and the structure of MgO/gC3N4. In vitro studies such as on ALP activity demonstrated the membrane's ability to regenerate new bone and healing capacity. Furthermore, alizarin red staining showed the increasing ability of the cell-cell interaction and calcium content for tissue regeneration. The cytotoxicity of the prepared membrane was about 97.09% of live THP-1 cells on the surface of the MgO/gC3N4@PAN/PEG membrane evaluated using MTT dye staining. The soil burial degradation analysis exhibited that the maximum degradation occurs on the 45th day because of microbial activity. In vitro PBS degradation was observed on the 15th day after the bulk hydrolysis mechanism. Hence, on the basis of the study outcomes, we affirm that the MgO/gC3N4@PAN/PEG nanofibrous membrane can act as a potential bone regenerative substrate.

Sustainable Routed Mxene-Based Aminolyzed PU/PCL Film for Increased Oxidative Stress and a pH-Sensitive Drug Delivery System for Anticancer Therapy.

A remarkable challenge in the anticancer drug delivery system is developing an implantable system that can improve the chemotherapeutic effect. Polyurethane is an excellent implantable substrate, with flaws in hydrophobicity. We modified polyurethane via the chemical aminolysis technique to enhance the wettability and protein interaction. The created pores can release the rutin complex incorporated in the polyurethane matrix. In this work, the hybrid polymer matrix consists of Mxene synthesized via a sustainable and simple method by introducing a toxic-free MAX phase and etchants. The incorporation of Mxene and PCL can enhance physicochemical and biological compatibility. Sustainable Mxene increases oxidative stress, cell death, and antibacterial activity, which also resulted in the Mxene@APU/PCL film. Meanwhile, the drug release with respect to pH sensitivity was demonstrated in which Mxene and Mxene@APU/PCL films showed the highest release at pH 5.2; this indicates that the prepared Mxene and aminolyzed polyurethane can function according to the biological system and release the drug from the polymer matrix on slow degradation and swellability. The Mxene and Mxene@APU/PCL films showed 93.2% drug release with oxidative stress on THP-1 cells, which causes rupturing and apoptosis of cancerous cells. The Mxene@APU/PCL film can show great potential in future implantable anticancer drug delivery systems.

CeO2@PU sandwiched in chitosan and cellulose acetate layer as Cs-CeO2@PU-CA triple-layered membrane for chromium removal.

The single or blended polymer membrane lacks a few advantages based on the durability of the membrane. The novel triple-layered sandwich membrane Cs-CeO2@PU-CA membrane is cast through the phase inversion technique for chromium removal. This approach involves an arrangement of the top layer as chitosan which acts as a protective layer, and the sandwich layer of CeO2@PU membrane which acts as source for stability, and a supportive layer of cellulose acetate is arranged accordingly. The incorporation of cerium oxide nanoparticles into the polyurethane can create pores on the surface of the membrane due to the high aspect ratio of cerium oxide. The triple-layered arrangement shows higher porosity via water contact angle, the network of pores present on the membrane which is visible through morphology, and also the intermediate sandwich layer CeO2@PU provided with better mechanical strength which would be significant for changes achieved in adsorption technique. The batch adsorption was carried out with various ppm of Cr(VI) solution. The effect of pH, contact time, initial concentration, and temperature were analyzed and optimized for determining efficiency of chromium removal. Furthermore, the suitable adsorption isotherm and kinetics of the system were also determined for better fit via Langmuir, Freundlich, Temkin, and Sips along with pseudo-first-order and pseudo-second-order. The efficiency in adsorption is due to the prominent presence of hydroxyl, carboxyl, and hydrophilic group in the prepared membrane. Thus, the resultant prepared membrane can act as a potential chromium removal substrate.