[Mechanisms of support prooxidant-antioxidant balance in the liver tissues of geese in hypo- and hyperoxia].

The mechanisms of support of the prooxidant-antioxidant balance in the liver tissues of geese in hypo- and hyperoxia during the transition from embryonic to postnatal development. It is proved that the formation of adaptive response to these conditions by running the neuro-humoral mechanisms that are, first, to stimulate the synthesis of antioxidants of protein nature, and secondly, to reduce the unsaturation of fatty acids in the lipids of the liver, which greatly increases their resistance to the active forms of oxygenation and thirdly, to increase the efficiency of the antioxidant defense system by improving the consistency of its components performance.

[Ontogenic characteristics of lipid peroxidation and antioxidant system enzymes in the brain of geese]. / Ontohenetychni osoblyvosti peroksydnoho okyslennia lipidiv ta fermentiv antyoksydantnoï systemy mozku husei.

Peculiarities of antioxidant homeostasis of geese brain tissue during embryogenesis and early postnatal period have been studied. It has been shown that the cerebrum and hindbrain tissues are characterized by a higher level of lipid peroxidation compared to liver. Main antioxidative enzymes' activity (superoxide dismutase, catalase, glutathione peroxidase) in the brain already reaches its maximum in the middle period of embryogenesis. We have found that brain tissues are characterized by a lower activity of intracellular enzymes (superoxide dismutase, catalase) but increased glutathione peroxidase activity as compared to liver. The rate of Fe2+ initialized lipid peroxidation and coefficient of antioxidative activity were used as a criterion for evaluation of antioxidative system's status. According to the dynamics of these factors the highest tension of antioxidative system in the brain appears in the period of the contour (28 days) and juvenile (49 days) feather formation.

[Ontogenic characteristics of changes in fatty acid composition of the liver lipids as a main substrate for peroxidation in geese]. / Ontohenetychni osoblyvosti zmin zhyrnokyslotnoho skladu lipidiv pechinky gusei iak holovnoho substratu peroksydatsiï.

Dynamics of fatty acid composition of geese liver lipids in embryogenesis and early postnatal period has been investigated. High nonsaturation of these tissues lipids is shown during all the period of researches. It is established, that in the second half of embryogenesis and in the beginning of postnatal period (first two weeks) the increase of oleic acid contents is observed with simultaneous decrease of the contents of the polynonsaturated fatty acids (PUFA) showing properties of endogenous bioregulators (arachidonic acid (AA), docosahexaenoic acid [figure: see text] (DHA). From the two-weeks age of gosling the contents of the mentioned acids changes in the opposite direction. The coordination of dynamics of TBA-active products with nonsaturation of fatty acids (FA) expressed in mEqu/g concerning double bonds, and also with respect to AA/DHA has been revealed.

[Features of the antioxidant homeostasis of goose liver in early postnatal ontogenesis]. / Osoblyvosti antyoksydantnoho homeostazu pechinky husei v rann'omu postnatal'nomu ontohenezi.

The research of features antioxidant status in early postnatal ontogenesis at the geese with an early target level pereoxidation is conducted. The very high target level of lipid pereoxidation (FLOOR) compared with the hens is shown, that at gees in norm. Are established (installed) laws of changes a FLOOR in liver of the geese on the first month of life.

[Formation of antioxidant defence system of geese in embryogenesis and early postnatal ontogenesis]. / Mekhanizmy formuvannia systemy antyoksydantnoho zakhystu v husei v embriohenezi ta rann'omu postnatal'nomu periodi.

The features of antioxidant protection of tissues of a liver and blood of the gooses in embriogenesis and early postnatal ontogenesis are found out. Maximal contents TBA active products both in a liver, and in a blood are observed in 28 diurnal embriones. Is shown, that in a liver the activity of basic antioxidant enzymes (superoxide dismutases, catalase and glutathione peroxidase) in a liver is developed already at early stages embriogenesis and is considerably enlarged in the end embriogenesis. The becoming of enzymatic system of a blood descends much more slower.