Cognition-Emotion Interaction during L2 Sentence Comprehension: The Correlation of ERP and GSR Responses to Sense Combinations.

This study mainly examined the role of the combination of three senses (i.e., auditory, visual, and tactile) and five senses (i.e., auditory, visual, tactile, olfactory, and gustatory) in the correlation between electrophysiological and electrodermal responses underlying second language (L2) sentence comprehension. Forty subjects did two acceptability judgment tasks, encompassing congruent and semantically/pragmatically incongruent sentences. The event-related potential (ERP) and galvanic skin response (GSR) data for both the target and final words of the sentences were collected and analyzed. The results revealed that there is an interaction between cognitive and emotional responses in both semantically and pragmatically incongruent sentences, yet the timing of the interaction is longer in sentences with pragmatic incongruity due to their complexity. Based on the ERP and GSR correlation results, it was further found that the five-sense combination approach improves L2 sentence comprehension and interest in learning materials yet reduces the level of excitement or arousal. While this approach might be beneficial for some learners, it might be detrimental for those in favor of stimulating learning environments.

A correlational study between microstructural, macrostructural and functional age-related changes in the human visual cortex.

Age-related changes in the human brain can be investigated from either structural or functional perspectives. Analysis of structural and functional age-related changes throughout the lifespan may help to understand the normal brain development process and monitor the structural and functional pathology of the brain. This study, combining dedicated electroencephalography (EEG) and magnetic resonance imaging (MRI) approaches in adults (20-78 years), highlights the complex relationship between micro/macrostructural properties and the functional responses to visual stimuli. Here, we aimed to relate age-related changes of the latency of visual evoked potentials (VEPs) to micro/macrostructural indexes and find any correlation between micro/macrostructural features, as well. We studied age-related structural changes in the brain, by using the MRI and diffusion-weighted imaging (DWI) as preferred imaging methods for extracting brain macrostructural parameters such as the cortical thickness, surface area, folding and curvature index, gray matter volume, and microstructural parameters such as mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). All the mentioned features were significantly correlated with age in V1 and V2 regions of the visual cortex. Furthermore, we highlighted, negative correlations between structural features extracted from T1-weighted images and DWI. The latency and amplitude of the three dominants peaks (C1, P1, N1) of the VEP were considered as the brain functional features to be examined for correlation with age and structural features of the corresponding age. We observed significant correlations between mean C1 latency and GM volume averaged in V1 and V2. In hierarchical regression analysis, the structural index did not contribute to significant variance in the C1 latency after regressing out the effect of age. However, the age explained significant variance in the model after regressing out the effect of structural feature.

Functional and structural correlates of the preterm infant's brain: relating developmental changes of auditory evoked responses to structural maturation.

Functional responses recorded during the last trimester of gestation reveal that human sensory activity begins before birth, allowing the brain to process the external environment. Along with the maturation of the brain, new cognitive skills emerge in the human infant's brain. The development of non-invasive techniques provides the opportunity to study the relationship between brain structural maturation and cognitive development in vivo. Here, we aimed to relate developmental changes of the latency of cortical auditory evoked potentials (CAEPs) to a structural maturation index, presumed to be representative of myelination. CAEPs to syllables were recorded in 17 preterm neonates with a mean recording age of 30.5 weeks gestational age (28.4-32.2 wGA). The latency of the first peak of the global field power (GFP) was considered the functional feature of interest to be examined for correlation with age and the structural maturation index extracted from brain atlases of the corresponding term age. GFP latency significantly decreased with age (R2 = 0.311, p = 0.02). Structural maturation indices, calculated as the mean values of T1w/T2w image intensities, were extracted for various brain regions. We observed significant correlations between the maturation indices of the auditory-involved areas and the latency of the GFP first-peak, as well as age. In hierarchical models, neither the structural maturation index nor age contributed to significant additional variance in the GFP first-peak latency after accounting for the variance associated with the other parameter.

Neurodevelopment and asymmetry of auditory-related responses to repetitive syllabic stimuli in preterm neonates based on frequency-domain analysis.

Sensory development of the human brain begins prenatally, allowing cortical auditory responses to be recorded at an early age in preterm infants. Despite several studies focusing on the temporal characteristics of preterm infants' cortical responses, few have been conducted on frequency analysis of these responses. In this study, we performed frequency and coherence analysis of preterm infants' auditory responses to series of syllables and also investigated the functional brain asymmetry of preterm infants for the detection of the regularity of auditory stimuli. Cortical auditory evoked potentials (CAEPs) were recorded in 16 preterm infants with a mean recording age of 31.48 weeks gestational age (29.57-34.14 wGA) in response to a repetitive syllabic stimulus. Peak amplitudes of the frequency response at the target frequency and the first harmonic, as well as the phase coherence (PC) at the target frequency were extracted as age-dependent variables. A functional asymmetry coefficient was defined as a lateralization index for the amplitude of the target frequency at each electrode site. While the findings revealed a significant positive correlation between the mean amplitude at the target frequency vs. age (R2 = 0.263, p = 0.042), no significant correlation was observed for age-related changes of the mean amplitude at the first harmonic. A significant correlation was also observed between the mean PC and age (R2 = 0.318, p = 0.023). A right hemisphere lateralization over many channels was also generally observed. The results demonstrate that rightward lateralization for slow rate modulation, previously observed in adults, children and newborns, appears to be in place at a very young age, even in preterm infants.

A survey on stimuli for visual cortical function assessment in infants.

Visual processing, as a significant and complex functionality of the human brain, changes during the life span with the most developmental changes in the infancy. Different types of visual stimuli are needed for evaluating different functionalities of the infants' visual system. Selecting appropriate visual stimuli is an important issue in evaluating visual cortical functions in infants. Properties of stimulation influence responses of visual system and must be adjusted according to the age and specific function which is going to be investigated. In this review, the most commonly used stimuli to elicit visual evoked potentials (VEPs) are evaluated and characteristics of VEPs extracted by these stimulations are studied. Furthermore, various studies investigating different functionalities such as selectivity for orientation and directional motion are presented. Valuable results regarding emerging and maturation times of different functions and normative data for clinical diagnosis are provided by these studies.