RESUMO
PURPOSE: To evaluate how the interval between radiation and salvage surgery for advanced laryngeal cancer with free tissue transfer reconstruction influences complication rates. MATERIALS AND METHODS: This is a retrospective series of 26 patients who underwent salvage laryngectomy or laryngopharyngectomy with vascularized free tissue reconstruction (anterolateral thigh or radial forearm) following radiation or chemoradiation between 2012 and 2017 at a single academic center. The primary outcome was incidence of postoperative complications, including pharyngocutaneous fistula. Secondary outcomes included the need for a second procedure, time to resumption of oral feeding, feeding tube dependence, and hospital length of stay. RESULTS: Salvage surgery was performed for persistence (7/26, 27%), recurrence/new primary (12/26, 46%), and dysfunctional larynges (7/26, 27%). Twenty-two (85%) defects were reconstructed with an anterolateral thigh free flap and 4/26 with a radial forearm free flap (15%). There were no flap failures. There were significantly more complications in patients undergoing surgery within 12â¯months of completion of radiation therapy (7/12, 58%) versus those undergoing surgery after 12â¯months (1/14, 7%; pâ¯=â¯.02). Patients experiencing complications more often required a second procedure (4/7 vs. 0/1; pâ¯=â¯.02), experienced a longer delay to initiation of oral diet (61 vs. 21â¯days; pâ¯=â¯.04), and stayed in the hospital longer (28 vs. 9â¯days; pâ¯=â¯.01). CONCLUSIONS: Shorter intervals between definitive radiation and salvage laryngopharyngeal surgery with free tissue reconstruction increases postoperative complications, hospital length of stay, and the likelihood of feeding tube dependence. Reconstructive surgeons can use these findings to help guide preoperative patient counseling and assess postoperative risk.
Assuntos
Retalhos de Tecido Biológico/transplante , Neoplasias Laríngeas/radioterapia , Neoplasias Laríngeas/cirurgia , Laringectomia/métodos , Procedimentos de Cirurgia Plástica/métodos , Idoso , Quimiorradioterapia/métodos , Estudos de Coortes , Feminino , Retalhos de Tecido Biológico/irrigação sanguínea , Sobrevivência de Enxerto , Humanos , Neoplasias Laríngeas/mortalidade , Neoplasias Laríngeas/patologia , Masculino , Pessoa de Meia-Idade , Faringectomia/métodos , Prognóstico , Radioterapia/métodos , Recuperação de Função Fisiológica , Estudos Retrospectivos , Medição de Risco , Terapia de Salvação/métodos , Taxa de Sobrevida , Fatores de Tempo , Falha de Tratamento , Resultado do TratamentoRESUMO
Iatrogenic tracheobronchial disruption is a rare, life-threatening condition. Depending upon the extent of the injury, its location, and the condition of the patient, repair/reconstruction options may be limited. The natural history of bovine pericardium used to repair one such tracheal injury has been documented.