[Assessment of the relationship of inflammation markers, adipokines and parameters of lipid metabolism in patient].

Objective - to assess the changes and the relationship of inflammation markers, adipokine levels and lipid metabolism in overweight and obesity, with signs of the metabolic syndrome. The study involved 62 women aged from 25 to 50 years. Group 1 included women (n=20) with a BMI<27.0, with no signs of metabolic syndrome, group 2 (n=20) - with a BMI>27.0, who were overweight or obese, with no signs of metabolic syndrome, 3 group (n=22) with a BMI>27.0, having overweight or obesity and the presence of any signs of metabolic syndrome. We determined relative and absolute lymphocyte counts and neutrophil granulocytes in the blood, lipid spectrum, blood serum levels of apolipoprotein A-1 (ApoA-1), and apolipoprotein B (apoB), leptin, adiponectin, interleukin-1ß (IL-1ß), interleukin 6 (IL-6), C-reactive protein (CRP). It was noted (p≤0.001) an increase of CRP in the blood of obese women, regardless of the presence of the metabolic syndrome: its concentration in groups 2 and 3 reached 6.69±3.03 and 7.30±3.08 mg/l, respectively, against 2.39±1.66 mg/l in group 1. Increasing BMI was accompanied by (p≤0.01) increase in erythrocyte sedimentation rate (8.1±5.0; 14.3±8.7; 13.9±8.5 mm per hour, respectively, in groups 1, 2 and 3). In women from groups 1 and 3 an increase in triglycerides, accompanied by a decrease in HDL (r=-0.44; p<0.025 and r=-0,57; p<0.001, respectively), and increase of LDL cholesterol (r=1.0; p<0.001) has been shown. The maximum number of positive correlations between indicators of lipid profile and inflammation markers was found in group 1, the minimum in group 3. This analysis showed the presence of chronic inflammation, which was accompanied by various disorders of lipid metabolism, even in the absence of clinical signs of pathology, the severity of which increased with increasing BMI and the development of metabolic syndrome.

[Reaction of the carp Cyprinus carpio L. at different periods of its ontogeny to the action of organophosphorus compounds]. / Reaktsiia karpa Cyprinus carpio L. v raznye periody ontogeneza na deistvie fosfororganicheskikh soedinenii.

Effect of some organic phosphorous compounds on the carp Cyprinus carpio L. in consecutive stages of its development has been studied. The least and most vulnerable stages in carp's development under the action of these compounds have been identified. The gravity of disorders in fish organism on early stages and the degree of pathological changes induced by organic phosphorous compounds have been shown. Embryotoxic and gonadotoxic effect of these compounds has been found.

[Characteristics of plastic metabolism and inorganic phosphorus absorption in Lymnaea stagnalis L. in prolonged exposure to a toxic agent]. / Osobennosti plasticheskogo obmena i pogloshcheniia neorganicheskogo fosfora u Lymnaea stagnalis L. pri dlitel'nom vozdeistvii toksikanta.

The influence of fungicide trimethyltinchloride upon the metabolism and K2H32PO4 uptake in Limnaea stagnalis L. in the process of its growth has been examined. The mollusks sensitivity of the different age groups to the toxic effect of this compound are determined.