[Significance of the chronic hypoxia and neurohormonal activity in the pathogenesis of ischemic heart disease]. / Znachenie khronicheskoi gipoksii i neirogormonal'noi aktivnosti v patogeneze ishemicheskoi bolezni serdtsa.

Two kinds of changes in the myocardium were found in the heart beyond the focus of necrosis in people of two age groups (senescent and senile) dying of miocardium infarction. Changes of the first kind (hypoxic) reflect the influence of chronic hypoxia of coronoarogenic origin, are always regional and characterized by fields of optically "empty" muscle fibers with reduced enzymatic activity under sacrolemma and frequently by the presence of non-oriented glycogen granules. Those of the second kind correspond to cardiotoxic effect of high doses of catecholamines and are represented by numerous disseminated micronecroses, focal or diffuse lipid infiltration with myocytes against the background of stromal edema with cell reaction and hemorrhages in it. Cases are considered in which hypoxic and cardiotoxic changes were predominant. Their comparison with the activity of the hypothalamo-hypophysis-adrenal system determined by morphological and histochemical tests (very high and moderately high) revealed some correlation.

[Enzymatic heterogeneity of the rat myocardium]. / Ob énzimaticheskoi geterogennosti miokarda krys

The histoenzymatic method was applied to the study of distribution of the activity of the redox enzymes in the myocardium of the ventricles in rats; distribution of the activity of lactic and malic dehydrogenase and of alpha-glycerophosphate proved to be the most manifest near the apex of the heart and was expressed in the presence of "spotty" areas of increased activity against the general homogeneous background of formazan deposits. The activity of mitochondrial upsilon-glycerophoric dehydrogenase was seen in all the portions of the ventricles and was characterized by an uneven distribution in the sarcoplasm with increase in the direction from the interdisc to the nucleus. Unevenness of distribution of the beta-oxybutyric dehydrogenase activity was detected in some of the animals and was pronounced in all the portions of the myocardium. The intensity of the reaction in detection of succinic dehydrogenase, NAD- and NADP-diaphorases varied but insignificantly.