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1.
J Comp Pathol ; 150(2-3): 245-52, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24447571

RESUMO

This paper reports a newly described form of skeletal dysplasia affecting Brazilian hair sheep of the Cabugi breed. This breed is characterized by having a short head and in some cases the animals are smaller and more compact than sheep of similar breeds. Lambs born with craniofacial abnormalities and dwarfism that die at 2-6 months of age are frequent in this breed. In a flock of 68 ewes and three rams of the Cabugi breed, 134 lambs were born over a 4-year period. Of these, 14 (10.4%) had marked cranial abnormalities and dwarfism and died or were humanely destroyed, 43 (32%) had a normal face and 77 (57.5%) had the short face characteristic of the breed. Dwarf lambs were much smaller than normal, with short legs, a domed head with retruded muzzle and protruded mandible, sternal deformities and exophthalmic eyes situated more laterally in the face than normal. Microscopical examination of long bones of the limbs, bones of the base of the skull and vertebrae showed no lesions. Bones from four affected lambs and one control lamb were macerated for morphometric examination. Although the length of the spinal cord was similar, there was disproportionate shortening of the appendicular bones, particularly the distal segments. Thus the disease was defined as a skeletal dysplasia characterized by craniofacial deformity and disproportionate dwarfism. It is suggested that the disease is inherited as an incomplete dominant trait. The shortened face, which is a feature of the Cabugi breed, may represent the heterozygous state and the more severe, often lethal, dwarfism may occur in homozygotes.


Assuntos
Doenças do Desenvolvimento Ósseo/veterinária , Anormalidades Craniofaciais/veterinária , Nanismo/veterinária , Doenças dos Ovinos/patologia , Animais , Doenças do Desenvolvimento Ósseo/genética , Doenças do Desenvolvimento Ósseo/patologia , Brasil , Anormalidades Craniofaciais/genética , Anormalidades Craniofaciais/patologia , Nanismo/genética , Nanismo/patologia , Feminino , Masculino , Fenótipo , Ovinos , Doenças dos Ovinos/genética
2.
Toxicon ; 51(2): 316-9, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18078971

RESUMO

Bone and other malformations caused by the ingestion of Mimosa tenuiflora are common in ruminants in the Brazilian semiarid. The aim of this research was to study the teratogenic effects of M. tenuiflora in Wistar rats (Rattus novergicus). The experimental group had 15 females and was fed, from the 6th to the 21st day of pregnancy, with a ration containing 10% of M. tenuiflora seeds. The control group, with 10 females, was fed with the same ration without seeds. There were no differences in weight gains, and food and water consumption between treated and control rats. Ninety bone malformations were observed in 40 of the 101 fetuses born in the experimental group, and four malformations were observed in three of the 58 fetuses born in the control group (p<0.05). The weight and number of ossification centers of the fetuses from the experimental group were higher than those from the control group (p<0.05). It is concluded that the seeds of M. tenuiflora are teratogenic to rat fetuses.


Assuntos
Mimosa/toxicidade , Teratogênicos/toxicidade , Animais , Anormalidades Congênitas/etiologia , Anormalidades Congênitas/patologia , Modelos Animais de Doenças , Feminino , Gravidez , Ratos , Ratos Wistar , Sementes
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