Avaliação da atividade antiinflamatória do coentro (Coriandrum sativum L. ) em roedores / Evaluation of the anti-inflammatory activity of coriander (Coriandrum sativum L. ) in rodents

Coriandrum sativum L. (Umbelliferae), conhecido popularmente por coentro, é uma planta doméstica cultivada nas diversas partes do mundo, inclusive no Brasil. As folhas e frutos do coentro são utilizados como condimento em culinária e na medicina popular como analgésica, antirreumática, carminativa e colagoga. O objetivo deste estudo foi avaliar o efeito do tratamento com o óleo essencial (OEC) e o extrato hidroalcóolico (EHC) do coentro em modelos experimentais de inflamação em roedores. A atividade antiinflamatória do coentro foi avaliada por meio dos testes de pleurisia em ratos e formação do edema de orelha em camundongos. A pleurisia foi induzida pela carragenina em animais tratados ou não com EHC. O edema de orelha induzido pela aplicação tópica de óleo de cróton e a atividade da mieloperoxidase foi avaliada em camundongos tratados ou não com OEC ou EHC. No teste da pleurisia o tratamento com EHC promoveu significativa diminuição no edema pleural, mas não sobre a migração leucocitária. Além disso, diferentemente ao observado com o tratamento com OEC, o uso tópico de EHC diminui significativamente o edema de orelha e a migração celular induzidos pela aplicação do óleo de cróton. Os dados indicam que EHC apresenta atividade antiinflamatória quando administrado pelas via oral e tópica, enquanto que OEC não apresenta atividade antiinflamatória tópica.

Commonly known as coriander, Coriandrum sativum L. (Umbelliferae) is a home plant grown in several parts of the world, including Brazil. Its leaves and fruits have been used as condiment in cooking and in folk medicine as analgesic, antirheumatic, carminative and cholagogue. The aim of this study was to evaluate the effect of essential oil (EO) and hydroalcoholic extract (HE) from coriander on experimental inflammation models in rodents. Coriander anti-inflammatory activity was evaluated by pleurisy tests in rats and ear edema formation in mice. Pleurisy was induced by carrageenan in HE-treated or non-treated animals. The ear edema was induced by topical application of croton oil and the myeloperoxidase activity was evaluated in EO-treated and HE-treated or non-treated mice. In the pleurisy test, HE treatment significantly decreased pleural edema but not the leukocyte migration. Furthermore, differently from EO, the topical use of HE significantly decreased ear edema and cell migration induced by croton oil application. The results indicate that HE had anti-inflammatory activity when orally and topically administered, whereas EO did not present topical anti-inflammatory activity.

Computed tomography for dental implants: the influence of the gantry angle and mandibular positioning on the bone height and width.

OBJECTIVES: To investigate the effect of deviation of mandibular positioning, by changing the gantry angle, on the measured height and width of dental implant sites in reformatted cross-sectional computed tomography (CT) scans. METHODS: CT images of ten human dry mandibles were made in three gantry positions to simulate changes in patient positioning: (1) parallel to the lower base of the mandible (standard); (2) with a gantry inclination of +19 degrees ; and (3) with an inclination of -19 degrees . One examiner measured the bone height and width at selected sites in the images at three different times. Results were compared with a paired test in SAS 8.02. RESULTS: In relation to bone height, when the jaws were inclined to the inferior direction (gantry angle +19 degrees ), there was no statistically significant difference for any region studied. There was a statistically significant difference for the incisor region when the jaws were inclined to the superior direction (gantry angle -19 degrees ). With respect to the width of the bone rim, there was a statistically significant difference only for the region of the molars when the jaw was inclined to the inferior direction and for the region of the canine, when the inclination was to the superior direction. CONCLUSIONS: Errors in mandibular positioning of 19 degrees produced image discrepancies with regard to bone height and width which were not excessive. Thus, examinations do not have to be repeated owing to variation of mandibular positioning because the differences were lower than 10% of the value found for the standard position.