Virtual museum of congenital heart defects: digitization and establishment of a database for cardiac specimens.

Education and training of morphology for medical students, and professionals specializing in pediatric cardiology and surgery has traditionally been based on hands-on encounter with congenitally malformed cardiac specimens. Large international archives are no longer widely available due to stricter data protection rules, a reduced number of autopsies, attrition rate of existing specimens, and most importantly due to a higher survival rate of patients. Our Cardiac Archive houses about 400 cardiac specimens with congenital heart disease. The collection spans almost 60 years and thus goes back to pre-surgical era. Unfortunately, attrition rate due to desiccation has led to an increased natural decay in recent years. The present multi-institutional project focuses on saving the collection by digitization. Specimens are scanned by high-resolution micro-CT/MRI. Virtual 3D-models are segmented and a comprehensive database is built. We now report an initial feasibility study with six test specimens that provided promising results, however, adequate presentation of the intracardiac anatomy, including septa and cardiac valves requires further refinements. Computer assisted design methods are necessary to overcome consequences of pathological examination, shrinkage and/or distortion of the specimens. For a next step, we anticipate an expandable web-based virtual museum with interactive reference and training tools. Web access for professional third parties will be provided by registration/subscription. In a future phase, segmental wall motion data could be added to virtual models. 3D-printed models may replace actual specimens and serve as hands-on surgical training to elucidate complex morphologies, promote surgical emulation, and extract more accurate procedural knowledge based on such a collection.

Ruling out static latent homophily in citation networks.

Citation and coauthor networks offer an insight into the dynamics of scientific progress. We can also view them as representations of a causal structure, a logical process captured in a graph. From a causal perspective, we can ask questions such as whether authors form groups primarily due to their prior shared interest, or if their favourite topics are 'contagious' and spread through co-authorship. Such networks have been widely studied by the artificial intelligence community, and recently a connection has been made to nonlocal correlations produced by entangled particles in quantum physics-the impact of latent hidden variables can be analyzed by the same algebraic geometric methodology that relies on a sequence of semidefinite programming (SDP) relaxations. Following this trail, we treat our sample coauthor network as a causal graph and, using SDP relaxations, rule out latent homophily as a manifestation of prior shared interest only, leading to the observed patternedness. By introducing algebraic geometry to citation studies, we add a new tool to existing methods for the analysis of content-related social influences.

Risk and Ambiguity in Information Seeking: Eye Gaze Patterns Reveal Contextual Behavior in Dealing with Uncertainty.

Information foraging connects optimal foraging theory in ecology with how humans search for information. The theory suggests that, following an information scent, the information seeker must optimize the tradeoff between exploration by repeated steps in the search space vs. exploitation, using the resources encountered. We conjecture that this tradeoff characterizes how a user deals with uncertainty and its two aspects, risk and ambiguity in economic theory. Risk is related to the perceived quality of the actually visited patch of information, and can be reduced by exploiting and understanding the patch to a better extent. Ambiguity, on the other hand, is the opportunity cost of having higher quality patches elsewhere in the search space. The aforementioned tradeoff depends on many attributes, including traits of the user: at the two extreme ends of the spectrum, analytic and wholistic searchers employ entirely different strategies. The former type focuses on exploitation first, interspersed with bouts of exploration, whereas the latter type prefers to explore the search space first and consume later. Our findings from an eye-tracking study of experts' interactions with novel search interfaces in the biomedical domain suggest that user traits of cognitive styles and perceived search task difficulty are significantly correlated with eye gaze and search behavior. We also demonstrate that perceived risk shifts the balance between exploration and exploitation in either type of users, tilting it against vs. in favor of ambiguity minimization. Since the pattern of behavior in information foraging is quintessentially sequential, risk and ambiguity minimization cannot happen simultaneously, leading to a fundamental limit on how good such a tradeoff can be. This in turn connects information seeking with the emergent field of quantum decision theory.

Integration of Linguistic Markup into Semantic Models of Folk Narratives: The Fairy Tale Use Case.

Propp's influential structural analysis of fairy tales created a powerful schema for representing storylines in terms of character functions, which is straightforward to exploit in computational semantic analysis and procedural generation of stories of this genre. We tackle two resources that draw on the Proppian model - one formalizes it as a semantic markup scheme and the other as an ontology - both lacking linguistic phenomena explicitly represented in them. The need for integrating linguistic information into structured semantic resources is motivated by the emergence of suitable standards that facilitate this, and the benefits such joint representation would create for transdisciplinary research across Digital Humanities, Computational Linguistics, and Artificial Intelligence.