Assuntos
Plaquetas/química , Isquemia Encefálica/etiologia , Cálcio/análise , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Transtornos Cerebrovasculares/sangue , Transtornos Cerebrovasculares/tratamento farmacológico , Deformação Eritrocítica/efeitos dos fármacos , Nafronil/uso terapêutico , Doença Aguda , Idoso , Isquemia Encefálica/sangue , Isquemia Encefálica/tratamento farmacológico , Avaliação de Medicamentos , Humanos , Pessoa de Meia-IdadeRESUMO
A study was made of the distribution of antigens of the isoserological systems ABO, Rh-Hr, MNSs, Duffy, Lutheran, Kidd, Kell-Chellano, P and Lewis in 192 epileptics++ in the Armenian community. It was found that the SS phenotype was significantly positively associated with epilepsy, whereas negative relations were established with the SS and AB phenotypes. The remaining group blood markers cannot serve markers of epilepsy in the Armenian community. The segregation familial analysis demonstrated as well that the MNSs system is not related genetically to the HLA system and the gene of "predisposition" to epilepsy, coupled in the Armenian community with HLA-B27 (cross-B27) and HLA-DR3 antigens.
Assuntos
Antígenos de Grupos Sanguíneos/genética , Epilepsia/etiologia , Eritrócitos/imunologia , Antígeno HLA-B27/genética , Antígeno HLA-DR3/genética , Armênia , Suscetibilidade a Doenças , Epilepsia/sangue , Epilepsia/genética , Epilepsia/imunologia , Marcadores Genéticos/genética , Marcadores Genéticos/imunologia , Haplótipos/genética , Humanos , FenótipoRESUMO
The isoserologic systems, including AB, Rh-Hz, MNSs, Duffy, Kidd, Kell-Chellano, Lutheran, Diego, and Lewis ones were investigated in 50 patients with disseminated sclerosis and in the general population. An increased rate of the Duffy phenotype (a-b+) is reported in the patients versus the population control. Individuals with this phenotype are at three times as great a risk of developing disseminated sclerosis than those with the Duffy phenotype (a+b-). The Duffy antigen (b+) is considered as a possible genetic marker of the disease in the Armenian population.