RESUMO
The goal of this retrospective study is to assess if diabetic patients are more likely to develop urinary tract infection (UTI) within the context of ureteral obstruction. 804 patients that had received an emergency treatment by double J placement for ureteral stone were selected between January 2004 and December 2014 at the Clinique Saint Pierre d'Ottignies, Ottignies-Louvain-La-Neuve,Belgium. They were divided in two groups : patients with UTI associated and the control group with the non infected ones. In the group of infected patients, 82 were diabetic whereas they were 46 in the control group. There was a significant difference regarding the presence of diabetes between the group of patients with UTI and the control group (p inferior to 0.001). This study demonstrates that diabetic patients are at higher risk of urinary tract infection in case of ureteral obstruction, thus an invasive treatment could be considered faster.
Cette étude rétrospective a pour but de déterminer si les patients diabétiques sont plus à risque de développer une infection urinaire en cas d'obstruction urétérale. 804 patients ayant bénéficié de la mise en place d'une sonde JJ en urgence pour une lithiase urétérale ont été sélectionnés entre le 1er janvier 2004 et le 31 décembre 2014 à la Clinique Saint Pierre d'Ottignies, à Ottignies Louvain la Neuve, Belgique. Ces patients ont été répartis en 2 groupes suivant qu'ils étaient ou non suspects d'infection urinaire associée. Dans le groupe des patients infectés, 82 patients étaient diabétiques alors qu'ils étaient 46 dans le groupe des patients sans infection urinaire. Les résultats montrent qu'il existe une différence significative entre les deux groupes en présence de diabète (p inf�rieur a 0,001). Cette étude montre un risque accru d'infection urinaire en cas d'obstruction urétérale chez les patients diabétiques. Un traitement invasif pourrait donc être envisagé plus rapidement.
Assuntos
Complicações do Diabetes , Diabetes Mellitus , Obstrução Ureteral , Infecções Urinárias , Bélgica , Humanos , Estudos Retrospectivos , Fatores de Risco , Obstrução Ureteral/complicações , Infecções Urinárias/etiologiaRESUMO
Ddx5 and ddx17 are two highly related RNA helicases involved in both transcription and splicing. These proteins coactivate transcription factors involved in cancer such as the estrogen receptor alpha, p53 and beta-catenin. Ddx5 and ddx17 are part of the splicing machinery and can modulate alternative splicing, the main mechanism increasing the proteome diversity. Alternative splicing also has a role in gene expression level regulation when it is coupled to the nonsense-mediated mRNA decay (NMD) pathway. In this work, we report that ddx5 and ddx17 have a dual role in the control of the pro-migratory NFAT5 transcription factor. First, ddx5 and ddx17 act as transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration. Second, at the splicing level, ddx5 and ddx17 increase the inclusion of NFAT5 exon 5. As exon 5 contains a pre-mature translation termination codon, its inclusion leads to the regulation of NFAT5 mRNAs by the NMD pathway and to a decrease in NFAT5 protein level. Therefore, we demonstrated for the first time that a transcriptional coregulator can simultaneously regulate the transcriptional activity and alternative splicing of a transcription factor. This dual regulation, where ddx5 and ddx17 enhance the transcriptional activity of NFAT5 although reducing its protein expression level, suggests a critical role for ddx5 and ddx17 in tumor cell migration through the fine regulation of NFAT5 pathway.
