From Crisis to Insight: Navigating Public Health Challenges in an Aging Society-Lessons from Hong Kong's COVID-19 Experience.

This article critically examines the experience of Hong Kong (HK) with the COVID-19 pandemic and highlights the urgent need for effective public health responses in an aging society. As one of the world's fastest aging societies, Hong Kong's vulnerability to the consequences of pandemics is particularly pronounced due to low birth rates and high life expectancies. The city has experienced multiple waves of the COVID-19 virus, with the fifth wave causing some of the highest mortality rates in the world. However, through continuous learning and adaptation, HK's public health response has evolved to combat the crisis effectively. The discussion aims to highlight the importance of drawing from both positive and negative lessons from past epidemics and the critical role of public health systems in ensuring the well-being of older adults and the wider community. It emphasizes the need for sustained efforts to maintain and strengthen public health systems to tackle the ongoing and future public health challenges in an aging society.

A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2.

Coronaviruses are a group of known RNA virus which primarily infect the respiratory tract, and also neurological, enteric, and hepatic systems. Endemic outbreaks of Middle East Coronavirus Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) have been observed in recent decades. A new strain named the SARS CoV-2(- COVID-19) virus has now spread across the globe. SARS-CoV-2 is highly communicable and has culminated in a massive pandemic of COVID-19. Currently, no successful treatment is available. Therefore, an urgent need is there for new screening models that can aid in identifying the drugs with potential activity against COVID-19. The current review aims to discuss various in-silico, in- -vitro and in-vivo screening methods that can potentially be used to expedite the discovery of new active therapeutic candidates and vaccines, drug targets, and repurposing the commercially available drugs against COVID-19 for the effective management of the infection and thereby controlling this pandemic. Further, the current status of drugs and vaccines under clinical investigation has been summarized.