1.
Eksp Klin Farmakol
; 55(4): 41-2, 1992.
Artigo
em Russo
| MEDLINE
| ID: mdl-1458188
RESUMO
The rat experiments studied the impact of inductors and inhibitors of enzymatic activity of xenobiotic metabolism on the pharmacological activity of sodium thiopental and ketamine and on the pharmacokinetics of sodium thiopental. Cocarboxylase, cobalt chloride and cimetidine enhanced the pharmacological action of sodium thiopental, but failed to exert any action on the effect of ketamine. The preparations of vitamin K, particularly vikasol and menadione sodium bisulfite, and phenobarbital attenuated the effects of these anesthetics, but tocopherol unchanged it. Phenobarbital and vikasol accelerated blood elimination of sodium thiopental, whereas cimetidine and cocarboxylase slowed down this process.
Assuntos
Inibidores Enzimáticos/farmacologia , Ketamina/farmacologia , Tiopental/farmacologia , Tiopental/farmacocinética , Animais , Interações Medicamentosas , Indução Enzimática/efeitos dos fármacos , Masculino , Ratos , Ratos Wistar , Tiopental/sangue
2.
Klin Khir (1962)
; (12): 50-1, 1991.
Artigo
em Russo
| MEDLINE
| ID: mdl-1798265
3.
Klin Khir (1962)
; (12): 61-2, 1989.
Artigo
em Russo
| MEDLINE
| ID: mdl-2632972