1.
Bioorg Med Chem Lett
; 20(16): 4945-50, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20621472
RESUMO
The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERbeta binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.