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Eye (Lond) ; 29(7): 958-63, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25998946

RESUMO

PURPOSE: To study the clinical and histopathological features of eyelid sebaceous gland carcinoma (SGC) and to evaluate the prognosis in the Asian-Indian population. METHODS: This is a retrospective study of 191 patients with SGC. RESULTS: The mean age at presentation of eyelid SGC was 57 years (median, 56 years). The tumor epicenter was most commonly located in the upper eyelid (n=125, 65%). The mean tumor basal diameter was 15 mm (median, 10 mm). There was evidence of tumor extension into the orbit (n=30, 16%), paranasal sinuses (n=3, 2%), and brain (n=1, 1%). Wide excision biopsy (n=146, 78%) was the most common treatment modality. Tumor recurrence was noted in 42 (24%) patients over a mean follow-up period of 29 months (median, 20 months). On the basis of the Kaplan-Meier estimate, lymph node metastasis occurred in 18%, systemic metastasis was detected in 10%, and death occurred in 2% of patients at 10 years. On multivariate analysis, the factors predicting locoregional lymph node and systemic metastasis were medial canthal involvement (P=0.004; P=0.013), lateral canthal involvement (P=0.013; P=0.025), tumor basal diameter >10 mm (P=0.002; P=0.002), and perivascular invasion (P=0.043; P<0.001), respectively. The factors predicting death due to metastasis on multivariate analysis were medial canthal involvement (P=0.012) and tumor basal diameter >10 mm (P=0.001). CONCLUSION: Advanced eyelid SGC is a tumor associated with poor prognosis. In this study, canthal involvement, larger tumor diameter, and perivascular invasion were poor prognostic factors.


Assuntos
Adenocarcinoma Sebáceo/patologia , Neoplasias Palpebrais/patologia , Neoplasias das Glândulas Sebáceas/patologia , Adenocarcinoma Sebáceo/etnologia , Adenocarcinoma Sebáceo/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Povo Asiático/etnologia , Neoplasias Palpebrais/etnologia , Neoplasias Palpebrais/terapia , Feminino , Humanos , Índia/epidemiologia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/diagnóstico , Estudos Retrospectivos , Neoplasias das Glândulas Sebáceas/etnologia , Neoplasias das Glândulas Sebáceas/terapia , Adulto Jovem
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