1.
Pediatr Infect Dis J
; 39(7): e120-e122, 2020 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32221169
RESUMO
Hydroxychloroquine (HCQ) suppresses an interleukin-1ß-granulocyte-macrophage colony-stimulating factor cytokine axis, reported to be dysregulated in peripheral blood mononuclear cells of acute rheumatic fever patients ex vivo. We describe HCQ treatment for 2 patients with rheumatic carditis and a protracted inflammatory course. HCQ was associated with control of inflammatory markers, control of pericarditis in first patient and stabilization of progressive carditis in the second patient.