[The interstitial electrophoresis of antibiotics in treating peritonitis in children]. / Vnutritkanevoi élektroforez antibiotikov v lechenii peritonita u detei.

The method was successfully used in 32 children with diffuse and general peritonitis and it may be recommended for clinical practice. No complications resulting from using the method of interstitial electrophoresis were noted.

[Experimental and clinical study of nitazol as an antibacterial drug in the complex treatment of peritonitis]. / Eksperimental'no-klinicheskoe izuchenie nitazola kak antibakterial'nogopreparata v kompleksnom lechenii peritonitov.

Antibacterial properties of the Soviet drug nitazol which is a derivative of imidazole were studied. It was shown that nitazol in a dose of 4-8 micrograms/ml was highly active against gram-negative nonsporulating anaerobes, gram-positive anaerobic cocci and spore-forming Clostridia spp. Unlike metronidazole, it was efficient against both standard and clinical strains of facultative anaerobes such as E. coli, S. aureus and Klebsiella spp. isolated from patients with peritonitis and being poly-resistant to antibiotics. It was found in vitro that the antibacterial effect of nitazol was higher when it was used in combination with some antibiotics. It was demonstrated on experimental models of peritonitis caused by Staphylococcus spp. and E. coli in mice that nitazol used alone or in combination with gentamicin had a favourable effect on the animal survival and lifespan. The combination of nitazol with gentamicin was applied in the combined treatment of appendicular peritonitis in 80 children and its high therapeutic efficacy was stated. Nitazol is useful as an antibacterial drug in the combined treatment of children with purulent peritonitis.

[Antibacterial activity of nitazole and its use in combined treatment of appendicular peritonitis in children]. / Antibakterial'naia aktivnost' nitazola i primenenie ego v kompleksnom lechenii appendikuliarnogo peritonita u detei.

The experimental-clinical investigations have demonstrated the high effectiveness of the native preparation Nitazole against the Gram-negative non-spore-forming anaerobic bacteria, Gram-positive anaerobic cocci, spore-forming Clostridium, certain facultative anaerobes. This permits to recommend it for the use as an antibacterial preparation for the treatment of peritonitis in children.