RESUMO
A case of marble bone disease in a 7-month-old child is presented. A genetical assessment showed a sporadic type of inheritance. Pathologic bone formation with a replacement of the bone marrow spaces of the pelvic bones, vertebrae, long bones, extramedullary haemopoiesis in the liver, lymph nodes, skull bones are found morphologically.
Assuntos
Osteopetrose/patologia , Medula Óssea/patologia , Osso e Ossos/patologia , Humanos , Lactente , Masculino , Osteopetrose/congênitoRESUMO
Physical methods were used in rat experiments to study the effect of acute pressure chamber hypoxia on the pulmonary surfactant in pulmonary extracts of different concentrations, bronchoalveolar washing and extract after washing. The surfactant activity in health and disease depended on the substrate and its concentration. The corrective coefficients for comparison of the surface activity of different substrates were calculated. Acute hypoxia induced a decrease in pulmonary surfactant activity. During deadaptation, the cellular surfactant first returns to normal followed by normalization of the extracellular surfactant.