RESUMO
1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow-release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half-lives were longer after food with conventional tablets, presumably due to continued absorption. The opposite effect was seen with slow-release tablets. 3 Slow-release oxprenolol is, under the conditions of this study, a reliable and convenient dosage form, providing similar plasma-drug profiles in fasted and nonfasted individuals.
Assuntos
Jejum , Oxprenolol/metabolismo , Adulto , Disponibilidade Biológica , Preparações de Ação Retardada , Feminino , Humanos , Cinética , Oxprenolol/administração & dosagem , Fatores de TempoRESUMO
1. The administration of beta-bromostyrene to the rat results in a fall in the level of hepatic glutathione. 2. Marmosets, rabbits and rats dosed with beta-bromostyrene excrete two mercapturic acids. One of these, N-acetyl-S-(2-hydroxy-2-phenyl-1-bromoethyl)-cysteine is readily converted into N-acetyl-S-(1-phenyl-2-bromo-2-ethenyl)-cysteine, the structure of which was established by mass spectrometry. 3. Mass spectrometric evidence suggests that the second mercapturic acid is N-acetyl-S-(1-hydroxy-2-phenylethyl)cysteine. 4. Mandelic acid was detected as a metabolite in all three species.
Assuntos
Aromatizantes/metabolismo , Estirenos/metabolismo , Animais , Callitrichinae , Cisteína/análogos & derivados , Cisteína/metabolismo , Feminino , Glutationa/metabolismo , Haplorrinos , Técnicas In Vitro , Fígado/metabolismo , Masculino , Coelhos , Ratos , Especificidade da Espécie , Fatores de TempoRESUMO
1 Plasma and saliva levels of metoprolol and oxprenolol have been compared in two groups of healthy volunteers. 2 Mean salivary oxprenolol levels were lower than, but closely related to the corresponding plasma levels (r=0.93), the mean ratio of saliva:plasma concentration being 0.42. 3 Mean salivary metoprolol concentrations were considerably greater thatn the corresponding plasma levels and the relationship between the concentrations in the two fluids was less clear. 4 The evidence presented suggests that oxprenolol diffuses passively whilst metoprolol is actively secreted into saliva. The mechanism involved in the active process is not known.
