Assuntos
Vacinas Bacterianas , Imunidade Ativa , Rickettsia rickettsii/imunologia , Febre Maculosa das Montanhas Rochosas/imunologia , Vacinação , Testes de Aglutinação , Anticorpos Antibacterianos/análise , Formação de Anticorpos , Vacinas Bacterianas/administração & dosagem , Testes de Fixação de Complemento , Humanos , Febre Maculosa das Montanhas Rochosas/diagnóstico , Febre Maculosa das Montanhas Rochosas/prevenção & controleAssuntos
Malária/sangue , Albumina Sérica , Soroglobulinas , Proteínas de Ligação a Tiroxina/sangue , Tiroxina/sangue , Tularemia/sangue , Febre Tifoide/sangue , Autorradiografia , Proteínas Sanguíneas , Cromatografia em Camada Fina , Diálise , Eletroforese , Humanos , Iodo/sangue , Isótopos de Iodo , Masculino , Ligação ProteicaRESUMO
Adult male volunteers were orally vaccinated with two "killed" antityphoid preparations. The recommended doses of both vaccines resulted in serum antibody development in only a few of the subjects. When the dose of the monovalent preparation (Taboral) was doubled, serological responses occurred more frequently, with a rise in O agglutinins in nearly one-fifth of the subjects, in H agglutinins in approximately one-fourth, and in Vi antibodies in nearly half.When vaccinated volunteers were fed virulent typhoid organisms, disease occurred less frequently among those men vaccinated with Taboral at twice the recommended dose (38%) than among those not vaccinated (54%). This preparation did not confer protection at the recommended dose.Volunteers who had previously recovered from an induced typhoid infection received a further challenge with virulent organisms. These persons developed typhoid fever less frequently (23%) than individuals without prior typhoid exposure (30%).