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1.
Sci Rep ; 13(1): 21938, 2023 12 11.
Artigo em Inglês | MEDLINE | ID: mdl-38081841

RESUMO

Hepatitis C infection and HIV/AIDS contaminations are normal in certain areas of the world, and because of their geographic overlap, co-infection can't be precluded as the two illnesses have a similar transmission course. This current work presents a co-infection model of HIV/AIDS and Hepatitis C virus with fuzzy parameters. The application of fuzzy theory aids in tackling the issues associated with measuring uncertainty in the mathematical depiction of diseases. The fuzzy reproduction number and fuzzy equilibrium points have been determined in this context, focusing on a model applicable to a specific group defined by a triangular membership function. Furthermore, for the model, a fuzzy non-standard finite difference (NSFD) technique has been developed, and its convergence is examined within a fuzzy framework. The suggested model is numerically validated, confirming the dependability of the devised NSFD technique, which successfully retains all of the key properties of a continuous dynamical system.


Assuntos
Síndrome da Imunodeficiência Adquirida , Coinfecção , Infecções por HIV , Hepatite C , Humanos , Hepacivirus , Infecções por HIV/complicações , Coinfecção/complicações , Síndrome da Imunodeficiência Adquirida/complicações , Hepatite C/complicações
2.
Sci Rep ; 13(1): 21993, 2023 12 11.
Artigo em Inglês | MEDLINE | ID: mdl-38081842

RESUMO

Salmonella Typhi, a bacteria, is responsible for typhoid fever, a potentially dangerous infection. Typhoid fever affects a large number of people each year, estimated to be between 11 and 20 million, resulting in a high mortality rate of 128,000 to 161,000 deaths. This research investigates a robust numerical analytic strategy for typhoid fever that takes infection protection into consideration and incorporates fuzzy parameters. The use of fuzzy parameters acknowledges the variation in parameter values among individuals in the population, which leads to uncertainties. Because of their diverse histories, different age groups within this community may exhibit distinct customs, habits, and levels of resistance. Fuzzy theory appears as the most appropriate instrument for dealing with these uncertainty. With this in mind, a model of typhoid fever featuring fuzzy parameters is thoroughly examined. Two numerical techniques are developed within a fuzzy framework to address this model. We employ the non-standard finite difference (NSFD) scheme, which ensures the preservation of essential properties like dynamic consistency and positivity. Additionally, we conduct numerical simulations to illustrate the practical applicability of the developed technique. In contrast to many classical methods commonly found in the literature, the proposed approach exhibits unconditional convergence, solidifying its status as a dependable tool for investigating the dynamics of typhoid disease.


Assuntos
Febre Tifoide , Humanos , Febre Tifoide/microbiologia , Salmonella typhi
3.
Sci Rep ; 13(1): 15840, 2023 09 22.
Artigo em Inglês | MEDLINE | ID: mdl-37739986

RESUMO

The terms susceptibility, exposure, infectiousness, and recovered all have some inherent ambiguity because different population members have different susceptibility levels, exposure levels, infectiousness levels, and recovery patterns. This uncertainty becomes more pronounced when examining population subgroups characterized by distinct behaviors, cultural norms, and varying degrees of resilience across different age brackets, thereby introducing the possibility of fluctuations. There is a need for more accurate models that take into account the various levels of susceptibility, exposure, infectiousness, and recovery of the individuals. A fuzzy SEIR model of the dynamics of the measles disease is discussed in this article. The rates of disease transmission and recovery are treated as fuzzy sets. Three distinct numerical approaches, the forward Euler, fourth-order Runge-Kutta, and nonstandard finite difference (NSFD) are employed for the resolution of this fuzzy SEIR model. Next, the outcomes of the three methods are examined. The results of the simulation demonstrate that the NSFD method adeptly portrays convergent solutions across various time step sizes. Conversely, the conventional Euler and RK-4 methods only exhibit positivity and convergence solutions when handling smaller step sizes. Even when considering larger step sizes, the NSFD method maintains its consistency, showcasing its efficacy. This demonstrates the NSFD technique's superior reliability when compared to the other two methods, while maintaining all essential aspects of a continuous dynamical system. Additionally, the results from numerical and simulation studies offer solid proof that the suggested NSFD technique is a reliable and effective tool for controlling these kinds of dynamical systems.The convergence and consistency analysis of the NSFD method are also studied.


Assuntos
Sarampo , Humanos , Reprodutibilidade dos Testes , Simulação por Computador , Incerteza
4.
Comput Biol Med ; 148: 105673, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35803748

RESUMO

Numerical models help us to understand the transmission dynamics of infectious diseases. Since vectors transmit many diseases, vector host models are very important. The transmission dynamics of Dengue fever with an incubation period of the virus with fuzzy parameters have been analyzed in this article. Sometimes it is very difficult and almost impossible to collect numerical data as a fixed value. Due to the lack of precise numerical data for the parameters, the fuzzy model is considered here. Fuzzy theory is a very powerful mathematical tool for dealing with imprecision and uncertainties. In this article, the chance of the occurrence of dengue infection ßh(a), the recovery rate r(a) and the mortality rate of the human population µh(a) due to dengue fever are considered fuzzy numbers. The stability of equilibrium points of the model has been determined and a reproduction number has been derived respectively in a fuzzy sense. A numerical model is designed for the studied model having fuzzy parameters and some numerical experiments are performed which indicate that the proposed method shows positivity, stability, and convergence at each time step size. Hence the method preserves the essential features of the dynamic epidemic models.


Assuntos
Dengue , Doenças Transmitidas por Vetores , Animais , Humanos , Insetos Vetores , Modelos Biológicos
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