1.
Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.
Org Biomol Chem
; 10(17): 3448-54, 2012 May 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22434259
RESUMO
A 6-step procedure was developed for the synthesis of a new family of acyclic nucleoside phosphonates (ANPs), "PHEEPA" [(2-pyrimidinyl-2-(2-hydroxyethoxy)ethyl)phosphonic acids] in overall yields ranging from 4.5% to 32%. These compounds, which possess on one side a hydroxy function and on the other side a phosphonate group, can be considered either as potential antiviral agents or as transition state analogues of nucleoside phosphorylases such as thymidine phosphorylase.
Assuntos
Materiais Biomiméticos/química , Materiais Biomiméticos/síntese química , Técnicas de Química Sintética/métodos , Nucleosídeos/química , Organofosfonatos/química , Organofosfonatos/síntese química , Pirimidinas/química , Pirimidinas/síntese química , Timidina Fosforilase/química
2.
Org Lett
; 13(19): 5076-9, 2011 Oct 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21888337
RESUMO
Diastereoselective domino reactions of iminoalcohols and allenyl H-phosphinates produce chiral phosphorus bicycles in a regio- and stereoselective fashion. A predictive model for diastereoselection is used for these new chiral phosphinic esters.