RESUMO
INTRODUCTION: Because patients and patient organizations want to strengthen their role in the care pathway and drug evaluation and in order to improve pharmacovigilance activities, European competent authorities implemented regulations to allow direct reporting of adverse drug reactions related to medicinal products by patients in 2012. OBJECTIVES: To describe evolution and analyze determinants of patient reporting activity in France in order to assess patient involvement in pharmacovigilance. METHOD: Using the French national pharmacovigilance database, univariate and multivariate analyses were performed to compare the characteristics of adverse drug reaction (ADR) reports from patients and healthcare professionals (HCP) between 2011 and 2020. The relationship between regional patient ADR report activity and regional care provision and socio-professional characteristics was analyzed using the principal component analysis. RESULTS: A significant and higher increase in ADR reports over time from patients (r = 0.89, p < 0.001) compared to HCP (r = 0.27, p = 0.002) has been observed. Patient ADR report activities compared to HCP concerned more women (80% vs. 55%, p < 0.001), younger age classes (p < 0.001), reporting through web portal (83% vs. 17%, p < 0.001), and less serious events (26% vs. 63%, p < 0.001). In the principal component analysis, regional patient reporting activity was related to socio-professional categories, age classes, and densities of hospital beds and physicians. CONCLUSION: Our results confirm an increasing involvement of patients in ADR report activities. The determinants of patient reporting activities are not only related to drug and medical factors but also to social factors. Digital tools may also play a role in health democracy in pharmacovigilance.
Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Médicos , Humanos , Feminino , Participação do Paciente , Farmacovigilância , Sistemas de Notificação de Reações Adversas a Medicamentos , França , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologiaAssuntos
Inseticidas , Compostos Organotiofosforados , Carrapatos , Animais , Resistência a Inseticidas , Nova CaledôniaAssuntos
Doenças dos Bovinos/epidemiologia , Infestações por Carrapato/veterinária , Animais , Bovinos , Doenças dos Bovinos/parasitologia , Nova Caledônia , Estações do Ano , Infestações por Carrapato/epidemiologia , Infestações por Carrapato/parasitologia , Carrapatos/crescimento & desenvolvimentoRESUMO
Four species are considered valid for the genus Impalaia--I. tuberculata Mönnig, 1923, I. nudicollis Mönnig, 1931, I. okapiae van den Berghe, 1937 and I. taurotragi (Le Roux, 1936) Travassos, 1937. I. tuberculata var. longispiculata Wetzel and Fortmeyer- 1960 and I. aegyptiaca Soliman, 1958 are considered synonyms of I. tuberculata Mönnig, 1923. I. nudicollis of Daubney, 1933, Yeh, 1956 and Pande et al. 1962 are tentatively considered synonyms of I. tuberculata Mönnig, 1923 and I. dremomys Yen, 1973 is transferred to the genus Heligmonella Mönnig, 1927 and becomes Heligmonella dremomys (Yen, 1973) n. comb. Heligmonella dremomysi Durette-Desset, 1974 becomes Heligmonella moreli nom. nov.