Software para la Exploración Electroneuromiográfica con el equipo NEURONICA 4

Se desarrolló el software EMG Workplace para la exploración electroneuromiográfica con el equipo Neuronica 4. Este sistema permite la evaluación de la integridad funcional del aparato neuromuscular por medio de las técnicas de electromiografía, estudios de conducción nerviosa, Onda F, Reflejo H, Estimulación Nerviosa Repetitiva y Reflejo de Parpadeo, los cuales constituyen un poderoso instrumento para la detección de las enfermedades neuromusculares. En su desarrollo se utilizaron todas las facilidades que ofrece el lenguaje de programación Delphi, con el propósito de obtener un producto final de gran utilidad y sencillo en su manejo. El sistema incluye varias aplicaciones que se corresponden con las técnicas electroneuromiográficas más utilizadas en la clínica. Presenta las mismas posibilidades que otros equipos de la competencia y nuevas facilidades que son muy útiles para la presentación, procesamiento y almacenamiento de la información. EMGWorkplace hace más completo el trabajo con elelectromiógrafo cubano Neuronica 4. Sustituye el software desarrollado hace más de una década y que hoy en día no puede ejecutarse sobre este equipo, y lo pone a la altura de los equipos más avanzados en este campo(AU)

Abordajes contralaterales en el tratamiento quirúrgico de aneurismas cerebrales bilaterales / Contralateral approaches in the surgical treatment of bilateral cerebral aneurysms

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Zr-catalyzed electrophilic carbomagnesation of aryl olefins. Mechanism-based control of Zr-Mg ligand exchange.

[reaction: see structure] The first examples of efficient electrophilic Zr-catalyzed carbomagnesations are disclosed, where in contrast to previous catalytic carbomagnesations the alkyl moiety of the electrophile is transferred (vs that of the Grignard reagent). The identity of the Grignard reagent is manipulated so that Zr-Mg exchange is facilitated, leading to the formation of alkylmagnesium halide products.

[Longitudinal follow-up study of 64 children chronically infected with hepatitis B virus, treated and not treated with interferon]. / Seguimiento longitudinal de 64 niños crónicamente infectados por virus B, tratados y no tratados con Interferon.

With the purpose of knowing the spectrum of the disease we studied the outcome of 64 children chronically infected by Hepatitis B Virus (HBV): 38 treated with Interferon (INF) and 26 without treatment. The period of infection was no less than 8 months, the average age was 4.7 years, 39 boys, 25 girls, and the observation period was 5 years, 3 moths (range 6 months-14 years). We divided them in 2 groups: a) 40 patients AgeBH positive from which 26 received treatment. b) 24 patients AgeBH negative from which 12 received treatment. We used 5,000,000 U. of interferon per M2 3 times a week for 16 weeks. The results do not show statistically difference that might favor the use of INF in order to reach seroconversion neither of Age nor Ags. Meanwhile the age is significant in Ags seroconversion. This might lead us to the question if seroconversion is due to the natural course of the disease once the body gets rid of the virus, or to interferon treatment. During the study period only one case turned to cirrhosis (1.7%) and none to Hepato carcinoma.

[Functional classification of the elderly in primary health care: proposed method]. / Clasificación funcional del anciano en atención primaria de salud: propuesta de un método.

OBJECTIVE: To develop a method of functional classification of the elderly (FCE) in Primary Health Care and to define the age limit for considering someone "a frail elderly person." DESIGN: A descriptive study in two phases: a) the method's design by means of "brainwriting" and b) the evaluation of the method in a descriptive crossover study. SETTING: A rural medical consulting-room. PATIENTS AND OTHER PARTICIPANTS: The research team, in the design of the method; and the elderly population attending for health care (n = 131), in the method's evaluation. MEASUREMENTS AND MAIN RESULTS: The FCE method was based on the Katz (IK) and Lawton-Brodie (IL-B) indices and classified the patients as independent and at different levels of disability. Urinary incontinence (UI) was excluded from the IK. 85.4% of the patients were independent, which bore relation to age (p < 0.001), but not to gender. When UI was included in the IK, the number of people classified as disabled increased by 32% (CI 95%, 23-41%) over when it was not included. Yet 80% of patients with UI were independent. No differences in the percentage of disabled patients were observed when the cut-off age for detecting disabled patients varied from 75 to 80. CONCLUSIONS: The inclusion of UI as a negative factor in the IK gives rise to overestimates of the number of disabled people. In our study the data suggested that the age for considering an elderly person as 'frail' should be 80.

Software development kit for electrophysiological signals processing.

A software development kit (SDK) for electrophysiological signal processing (hardware control, storage, and graphic visualization) is presented. Its architecture is described, and emphasis is made on the underlying technology. Results obtained in continuous EEG and Evoked Potential monitoring at Cuban Neuroscience Center are presented.

Development of a database system for electrophysiological signals.

A relational database system was developed to store electrophysiological signals recorded with different Evoked Potentials (EP) recording equipment produced by the Cuban Neurosciences Center. The system has several functions such as storage of EP recording parameters, data retrieval with a flexible query mechanism, database backup, and data transfer from one database to other. A complete set of functions facilitates EP analysis, either for clinical or research purposes. It is also useful as a clinical information management tool.

[Chronic infection due to hepatitis B virus in patients less than 16 years of age: therapeutic approach by means of interferon alfa-2b]. / Infección crónica por virus B en pacientes menores de 16 años de edad: abordaje terapéutico mediante interferón alfa 2b.

Twenty children with chronic Hepatitis B virus infection where treated with alfa interferon 2b and compared with a group of 24 non treated patients with similar age and sex distribution. Both treated and untreated patients, all Hepatitis B surface antigen positive for a minimum of 6 months, were divided in 2 groups according to HBeAg status: positive and negative. The treatment was ambulatory at a dose of 5.000.000 U per square meter of body surface, administered 3 times a week during 16 weeks. Tolerance of the drug was good with secondary reactions only at the beginning of the treatment. The only change in laboratory tests was the normalization of aminotransferases in HBeAg positive children. There was no significant difference between the treated and untreated group of HBeAg positive patients regarding the rate of HBeAg seroconversion. There was a striking difference in negativization of HBsAg in HBeAg negative patients: 8% in the treated group and 81% in the untreated group, this is explained by important epidemiological differences between both groups.

[Prevalence of the antibody of hepatitis C virus in HBsAg negative patients with chronic liver diseases: children, prostitutes, and homosexuals]. / Prevalencia del anticuerpo del virus C en pacientes con enfermedades crónicas hepáticas AgsHB negativos: niños; prostitutas y homosexuales.

We present the results of the determination of hepatitis C virus antibody, recently discovered on a group of 34 patients with chronic liver disease, divided in: a) 23 patients with cirrhosis. b) 8 with protracted hepatitis. c) 2 with steatosis of unknown origin++. d) One patients with hepatocellular carcinoma. Another group examined was integrated by persons of promiscuous sexual activity (15 prostitutes and 14 homosexuals). Finally we included 20 children chronically infected with VB. In the 23 patients with cirrhosis, the VB markers (HBsAg and anti-core were negative in 18 and 5 were only anti-core positive; anti-HCV was positive in 3 of the 18 VB negative (16.6%) and in one of the 5 with anti-core positive (20%), that represents a total of 4 cases anti-HCV positive (17.3%). 5 of the 8 patients with protracted hepatitis were virus B and A negative and 4 of them were anti-HCV positive (80%), 3 of which had parenteral infection. The 15 prostitutes and the 14 homosexuals were negative for the anti-HCV, as well as the 20 children chronically VB infected. Our result of the determination of anti-HCV in cryptogenetic cirrhosis (17.3%) is similar that reported in USA (> 20%) and very much lower than of the Italian group (80%). Meanwhile we found a high incidence in protracted hepatitis (80%) with parenteral infection.

Carcinoma de mama. Presentación de un hombre de 90 años de edad / Breast carcinoma

La poca frecuencia de la neoplasia de mama en el hombre, y lo excepcional de la misma, ha motivado nuestro trabajo. Revisando la literatura, consideramos, que este es el paciente más longevo con esta enfermedad, pues hasta ahora sólo se conocia un caso de 77 años. El antecedente de la tumoración previa en la mama, así como la ginecomastia, con factores predisponentes se constató en nuestro paciente. En nuestro caso se conmprobaron también metástasis ganglionares regionales y costales osteolíticas. No se encontraron antecedentes de tratamiento con estrógenos, ni alteraciones a nivel de la próstata (AU)