RESUMO
We have studied the Chacma baboon prostate in an attempt to develop a primate model of benign prostatic hyperplasia. Anatomically, the baboon prostate can be divided into caudal, cranial, and prostatic urethral segments. A peri-urethral group of glands has been identified in the prostatic urethra. Following treatment with either 5 alpha-androstane-3 alpha, 17 beta-diol or 17 beta-estradiol, or the hormones in combination, the mature baboon prostate showed very little response by gravimetric or morphometric analysis. In contrast, the stimulatory effect of 5 alpha-androstane-3 alpha, 17 beta-diol on the caudal lobe of the immature baboon prostate and the prostatic urethral segment (a structure that is largely fibromuscular) was potentiated by the addition of 17 beta-estradiol. The weight of the immature baboon cranial prostate was increased by 5 alpha-androstane-3 alpha, 17 beta-diol treatment, but 17 beta estradiol did not potentiate androgen-induced growth. By morphometric analysis it could be shown that both the epithelial and stromal component of the immature baboon caudal prostate responded to 5 alpha-androstane-3 alpha, 17 beta-diol (androstanediol) treatment and that the addition of 17 beta-estradiol had a slight, but significant, potentiating effect on the androstanediol-induced increase of epithelial volume.
Assuntos
Androstenodiol/farmacologia , Androstenodióis/farmacologia , Estradiol/farmacologia , Papio/fisiologia , Próstata/efeitos dos fármacos , Envelhecimento , Animais , Masculino , Próstata/anatomia & histologia , Próstata/fisiologia , Hiperplasia Prostática/patologia , Hiperplasia Prostática/fisiopatologiaRESUMO
Stress incontinence in women is a frequent and humiliating complaint, the aetiology and pathogenesis of which are not always apparent. Routine investigation followed by standard vaginal or abdominal surgical procedures will cure most uncomplicated cases. However, in complicated cases a more sophisticated pre-operative evaluation and a more versatile surgical approach are indicated in order to restore the changed anatomy and function.
Assuntos
Bexiga Urinária/cirurgia , Incontinência Urinária por Estresse/cirurgia , Adolescente , Adulto , Idoso , Feminino , Humanos , Métodos , Pessoa de Meia-Idade , Incontinência Urinária por Estresse/diagnóstico , Incontinência Urinária por Estresse/etiologiaRESUMO
Bladder neck incompetence is responsible for 15,5% of true anatomical defects that cause stress incontinence in the female. Confirmation of the diagnosis of this condition, as well as a new surgical technique for the repair of the defect, is described.
Assuntos
Doenças da Bexiga Urinária/cirurgia , Bexiga Urinária/cirurgia , Adulto , Feminino , Humanos , Métodos , Doenças da Bexiga Urinária/complicações , Incontinência Urinária por Estresse/etiologiaRESUMO
Tuberculosis of the male urethra and corpora cavernosa is discussed and 3 patients with this rare condition are presented. These patients were among 63 patients who presented with urethral stricture during the past 2 years. The diagnosis was based primarily on histological appearance, and treatment consisted of a combined medical and surgical approach, viz. streptomycin, PAS, INH with or without rifampicin; urinary diversion and drainage of pus (if any); initial stage I urethroplasty after control of infection and stage II urethroplasty after 18 - 20 months.
