Differential immunologic effects of language-dominant and nondominant cerebral resections.

OBJECTIVE: To demonstrate whether the cerebral hemispheres (language dominant versus nondominant) affect immune function differentially in humans by delineating the effects of resections for epilepsy surgery on T-cell indices. BACKGROUND: Cerebral lateralization has been postulated to affect immunomodulation. Differential effects of left versus right cerebral lesions on T-cell numbers and responsiveness have been demonstrated in animals, but the effects in humans are unclear. METHODS: Pre- and postoperative changes in T-cell indices were examined in relation to side of language dominance in patients undergoing epilepsy surgery. RESULTS: Absolute lymphocyte count, total T cells (CD3+), helper T cells (CD3+4+), cytotoxic/suppressor cells (CD3+8+), and total suppressor cells (CD8+) were reduced after language-dominant resections, but were increased after nondominant resections. CONCLUSIONS: Although the mechanisms are not fully elucidated, the results demonstrate differential immunologic responses in humans to focal cerebral lesions as a function of cerebral lateralization.

Suicide assessment: clinical interview vs. self-report.

This study examined whether patients disclosed the same information about suicidal behaviors on a self-report instrument that they conveyed to a clinician in a face-to-face interview. The results indicated a generally high level of agreement between these two forms of suicide assessment. The one exception was the question that concerns recent suicidal ideation, where patients tended to disclose more on the self-report form.