RESUMO
The secretory response of the exocrine pancreas to an intravenous bolus of secretin (1.0 U/kg) was studied in healthy men and women below and above 45 years of age. We studied the secretory pattern, i.e., electrolyte and enzyme secretion in 8 sequential, 10-min collections and cumulative values for each parameter. Within the male group, no significant changes were observed, except for higher amylase and lipase secretions in the older subjects. On the other hand, females over 45 yr old had secretory patterns that showed a decline of flow and of bicarbonate concentration and output. No significant secretory differences were observed in the groups of younger males and females. When the over-45 groups of men and women were compared, the women exhibited a significant decrease in bicarbonate concentration and output. Moreover, this group of women had a cumulative 80-min output of bicarbonate and lipase significantly below these parameters in the men. Possible mechanisms are discussed.
Assuntos
Pâncreas/metabolismo , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Amilases/metabolismo , Bicarbonatos/metabolismo , Feminino , Humanos , Lipase/metabolismo , Masculino , Pessoa de Meia-Idade , Secretina , Fatores SexuaisAssuntos
Alcoolismo/fisiopatologia , Colecistocinina/farmacologia , Vias Neurais/fisiopatologia , Pâncreas/metabolismo , Animais , Atropina/farmacologia , Sistema Biliar/fisiologia , Duodeno/inervação , Humanos , Masculino , Vias Neurais/efeitos dos fármacos , Pâncreas/fisiologia , Pâncreas/fisiopatologia , Sistema Nervoso Parassimpático/fisiopatologia , Pilocarpina/farmacologia , Ratos , Ratos Endogâmicos , Receptores Muscarínicos/efeitos dos fármacos , VagotomiaAssuntos
Alcoolismo/complicações , Colecistocinina , Pâncreas/fisiopatologia , Pancreatite/etiologia , Alcoolismo/fisiopatologia , Animais , Cães , Relação Dose-Resposta a Droga , Etanol/farmacologia , Gastrinas/fisiologia , Humanos , Vias Neurais/fisiopatologia , Pâncreas/efeitos dos fármacos , Pâncreas/metabolismo , Pancreatite/fisiopatologia , Ratos , Reflexo/efeitos dos fármacos , Reflexo/fisiologia , Secretina/fisiologiaRESUMO
The effects of chronic truncal vagotomy on the pancreatic gland was studied in male adult Wistar rats. Two to three months after parasympathetic decentralization, the gland weight was found to be significantly increased by nearly 100%. This trophic effect is mainly due to the proliferation of young acinar cells. Concomitantly, there is a decrease of the ductular mass and of the Langerhans islets. Choline acetylase activity was decreased by about 35% to 40% in the vagotomized pancreas. Further, enzyme concentration was found to be greater in the head than in the body and tail of the gland, thus suggesting a higher nerve density of vagal cholinergic fibers in the former than in the latter. Basal pancreatic secretion of the decentralized gland showed a significant increase in the flow rate with no significant changes in both bicarbonate concentration and output. Protein concentration was significantly reduced at 60 minutes; protein output remained unchanged. The most remarkable finding was the fall in both lipase concentration and output (60-70%) when compared with control values. These findings may be related to clinical manifestations after long-term vagotomy.
Assuntos
Pâncreas/fisiopatologia , Suco Pancreático/metabolismo , Vagotomia/métodos , Animais , Colina O-Acetiltransferase/metabolismo , Ducto Colédoco/fisiologia , Fístula , Lipase/metabolismo , Masculino , Pâncreas/patologia , Ratos , Ratos EndogâmicosRESUMO
The effects of chronic truncal vagotomy on the pancreatic gland was studied in male adult Wistar rats. Two to three months after parasympathetic decentralization, the gland weight was found to be significantly increased by nearly 100
. This trophic effect is mainly due to the proliferation of young acinar cells. Concomitantly, there is a decrease of the ductular mass and of the Langerhans islets. Choline acetylase activity was decreased by about 35
to 40
in the vagotomized pancreas. Further, enzyme concentration was found to be greater in the head than in the body and tail of the gland, thus suggesting a higher nerve density of vagal cholinergic fibers in the former than in the latter. Basal pancreatic secretion of the decentralized gland showed a significant increase in the flow rate with no significant changes in both bicarbonate concentration and output. Protein concentration was significantly reduced at 60 minutes; protein output remained unchanged. The most remarkable finding was the fall in both lipase concentration and output (60-70
) when compared with control values. These findings may be related to clinical manifestations after long-term vagotomy.
