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1.
J Clin Microbiol ; 43(10): 5348-50, 2005 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16208015

RESUMO

In the summer of 2003 a community-acquired outbreak of Legionella pneumophila occurred in Rome, Italy. Three molecular typing methods, pulse-field gel electrophoresis, amplified fragment length polymorphism analysis, and sequence-based typing (SBT), were used to establish the clonal correlation among the isolates of the epidemic cluster. By comparison of the methods, SBT was the most rapid and the easiest to perform and provided unambiguous results.


Assuntos
Técnicas de Tipagem Bacteriana , Surtos de Doenças , Legionella pneumophila/classificação , Legionella pneumophila/genética , Doença dos Legionários/epidemiologia , Proteínas de Bactérias/genética , DNA Bacteriano/análise , Eletroforese em Gel de Campo Pulsado , Humanos , Itália/epidemiologia , Legionella pneumophila/isolamento & purificação , Doença dos Legionários/microbiologia , Polimorfismo de Fragmento de Restrição , Análise de Sequência de DNA
2.
Biochem Med ; 34(3): 373-5, 1985 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-4096723

RESUMO

The effect of 5-km noncompetitive swimming (moderate exercise) and 2-km competitive speed swimming (intensive exercise) on protein breakdown was studied in a group of young male volunteers (16-20 years old) who followed a 3-MH-free diet throughout the study. Urinary 3-MH and creatinine were determined over a period of 24 and 48 hr as an index of protein degradation. Basal 3-MH levels in the two groups of swimmers were 2.85 and 3.07 mumole X kg-1 X day-1. Mean rates of 3-MH excretion were, respectively, 1.54 and 1.94 mumole X kg-1 X day-1 for the 48 hr after moderate exercise and the 24 hr after intensive exercise. The decrease in 3-MH urinary excretion was still evident when calculated as the urinary 3-MH-to-creatinine ratio.


Assuntos
Creatinina/urina , Histidina/análogos & derivados , Metilistidinas/urina , Esforço Físico , Proteínas/metabolismo , Adolescente , Adulto , Humanos , Masculino , Natação , Fatores de Tempo
3.
J Neurochem ; 43(5): 1484-6, 1984 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-6149262

RESUMO

Brain tissue from myodystrophic mice (male 129/ReJ-dy and female 129 B6F1/J-dy) was examined to determine whether CNS abnormalities accompany the known muscular defects. Brain N-acetyl-L-aspartate, aspartate, and glutamate were significantly lower than in brain from control mice. These amino acids are only slightly reduced in brains of female dystrophic mice.


Assuntos
Ácido Aspártico/análogos & derivados , Encéfalo/metabolismo , Distrofia Muscular Animal/metabolismo , Animais , Ácido Aspártico/metabolismo , Feminino , Glutamatos/metabolismo , Ácido Glutâmico , Masculino , Camundongos , Camundongos Mutantes , Fatores Sexuais
5.
Muscle Nerve ; 7(5): 388-91, 1984 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-6738577

RESUMO

Myofibrillar protein catabolic rate was calculated in 50 young patients with Duchenne muscular dystrophy from the amount of 3-methylhistidine excreted in the urine, and was found to be about seven times that of a control series, expressed as the percentage of myofibrillar protein catabolized per day. This wastage of myofibrillar protein is a consequence of Duchenne muscular dystrophy and inhibition of protein degradation appears to be one possible approach in the treatment of this disease.


Assuntos
Histidina/análogos & derivados , Metilistidinas/urina , Proteínas Musculares/metabolismo , Distrofias Musculares/urina , Miofibrilas/metabolismo , Criança , Pré-Escolar , Creatinina/urina , Humanos
6.
Res Commun Chem Pathol Pharmacol ; 43(3): 477-86, 1984 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-6718810

RESUMO

The content of 3-methylhistidine (3MH) and creatine was measured in the heart and in nine skeletal muscles of control and dystrophic Re 129/J mice. The mean 3MH level per unit of non-collagen protein (NCP) was significantly lower than normal in all but the heart muscles of dystrophic mice.


Assuntos
Histidina/análogos & derivados , Metilistidinas/metabolismo , Músculos/metabolismo , Distrofia Muscular Animal/metabolismo , Animais , Creatina/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos , Proteínas Musculares/metabolismo , Tamanho do Órgão
8.
Muscle Nerve ; 6(6): 423-9, 1983.
Artigo em Inglês | MEDLINE | ID: mdl-6621612

RESUMO

The content of 3-methylhistidine (3-MH) and 1-methylhistidine (1-MH) was measured in muscle biopsy specimens from 13 normal controls, 19 patients with Duchenne muscular dystrophy, 8 limb-girdle disease patients, and 23 disease controls with different forms of muscular pathology. 3-MH and 1-MH concentrations in normal human muscle did not appear to be influenced by sex, body weight, and age, at least for subjects in the 10--60 year age group examined. Skeletal muscle 1-MH levels did not significantly differ from mean control values in any of the pathologies investigated. In the patient population examined, the mean 3-MH level per unit of noncollagen protein (NCP) was significantly lower than normal in Duchenne dystrophy only, the reduction being related to disease severity. The significantly lower concentrations of 3-MH in muscle of Duchenne patients indicate the importance of measuring 3-MH in diseased muscle to obtain reliable estimates of the myofibrillar protein catabolic rate.


Assuntos
Histidina/análogos & derivados , Metilistidinas/metabolismo , Músculos/metabolismo , Doenças Musculares/metabolismo , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Proteínas Musculares/metabolismo , Atrofia Muscular/metabolismo , Distrofias Musculares/metabolismo
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