Animal experimental study of intra-articular injection of S-methylisothiourea for treatment of temporomandibular joint osteoarthrosis / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To investigate the efficacy of S-methylisothiourea (SMT) for treatment of temporomandibular joint osteoarthrosis (TMJOA) of goats.</p><p><b>METHODS</b>Nine purebred black goats were randomly devided into three groups: Normal control group, control group and experimental group. The upper compartments of both temporomandibular joint of the goats in control group and experimental group were injected with collagenase only once to induce osteoarthrosis. Normal control group received no treatment. The upper compartments of both TMJ were injected with 0.5 mL of normal saline, and experimental group, the upper compartments of both TMJ were injected with 0.5 mL of SMT. The TMJ of goats was examined with scanning electron microscopy and microscopy after sacrificed.</p><p><b>RESULTS</b>Examined in light microscopy and scanning electron microscopy, normal control group showed normal performance, the control group showed severe osteoarthrotic changes in the temporal surface, disk and condyle, while the experimental group showed improvement of different degree.</p><p><b>CONCLUSION</b>On the basis of 3-month following-up study, repeated intra-articular injection of SMT may play a role in inhibiting TMJOA progression.</p>

Relationship between transforming growth factor-alpha gene polymorphism and non-syndromic cleft lip with cleft palate / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To study the association of TGF-alpha gene polymorphism and non-syndromic cleft lip with cleft palate in Shandong province.</p><p><b>METHODS</b>Polymerase chain reaction combined with restrict enzyme digestion was used to detect the target gene variation in 98 patients with non-syndromic cleft lip with cleft palate and 101 healthy controls.</p><p><b>RESULTS</b>The C2 allele frequency in patients with non-syndromic cleft lip with cleft palate was significantly higher than that in healthy controls. The genotype frequency in patients with positive family history was significantly higher than that without positive family history.</p><p><b>CONCLUSION</b>TGF-alpha gene polymorphism is closely associated with non-syndromic cleft lip with cleft palate in Shandong, especially in patients with positive family history.</p>

Observation and contrast of anaerobe culturing result using three kinds of device / 医疗卫生装备

The positive ratio is 74 percent using the plate anaerobe culturing device made by author, higher than using common anaerobic box and anaerobic jar.