1.
Bioorg Med Chem Lett
; 11(20): 2735-40, 2001 Oct 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11591513
RESUMO
A series of new N-substituted derivatives of morphinan was synthesized and their binding affinity for the three opioid receptors (mu, delta, and kappa) was determined. A paradoxical effect of N-propargyl (MCL-117) and N-(3-iodoprop-(2E)-enyl) (MCL-118) substituents on the binding affinities for the mu and kappa opioid receptors was observed. All of these novel derivatives showed a preference for the mu and kappa versus delta binding.