RESUMO
The first reported cases of colonic carcinoma arising within a diverticulum are documented. Although colonic diverticulitis and cancer are common diseases in patients over 60 years of age, cancer arising within a diverticulum is rare. Only close histopathologic scrutiny can differentiate inflammatory changes from neoplasia. Because colonic diverticula are characteristically thin-walled, cancers arising within diverticula may easily penetrate the serosa and first be diagnosed at an advanced stage despite their small size.
Assuntos
Adenocarcinoma/etiologia , Neoplasias do Colo/etiologia , Doença Diverticular do Colo/complicações , Adenocarcinoma/patologia , Idoso , Idoso de 80 Anos ou mais , Neoplasias do Colo/patologia , Doença Diverticular do Colo/patologia , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A prospective study analysed the prognostic value of nm23-H1 allelic deletions in colorectal cancer. Of 21 patients with no evidence of distant metastases at initial operation, 11 showed nm23-H1 allelic deletions (including 1 homozygous deletion); 10 had no nm23-H1 deletions. After median follow-up of 25 months, distant metastases had developed in 8 of 11 (73%) patients with nm23-H1 deletions but in only 2 of 10 (20%) without nm23-H1 deletions (p less than 0.03). Tests with probe YNZ 22.1, near p53, showed no significant association with distant metastases. nm23-H1 may be, or may be located near, a late-acting suppressor gene in colorectal carcinoma, in which deletions may have prognostic value.
Assuntos
Alelos , Deleção Cromossômica , Neoplasias Colorretais/genética , Metástase Neoplásica/genética , Idoso , Sondas de DNA , Humanos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Estudos ProspectivosRESUMO
We describe a 62-year-old man with diabetes mellitus and peripheral vascular insufficiency, with an ulcer on his foot which led to staphylococcal septicemia, endocarditis, and disseminated intravascular coagulation. All these factors contributed to thromboembolic occlusion of the terminal arteries and veins supplying the stomach, causing gastric infarction.
Assuntos
Endocardite Bacteriana/complicações , Infarto/etiologia , Infecções Estafilocócicas/complicações , Estômago/irrigação sanguínea , Adolescente , Idoso , Complicações do Diabetes , Coagulação Intravascular Disseminada/etiologia , Feminino , Doenças do Pé/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Úlcera Cutânea/microbiologia , Staphylococcus aureus/isolamento & purificaçãoRESUMO
Bile emboli in the kidneys and lungs were present at autopsy in a patient who had undergone percutaneous trans-hepatic drainage for pancreatic carcinoma obstructing the common bile duct. The patient also developed hemobilia and bile peritonitis.
