RESUMO
The study involved a group of 33 males with diagnosed alcohol abuse. A degree of the disease was determined according to Standard Anamnesis Sheet and Auxilliary Alcohol Dependence Questionnaire (Woronowicz's Questionnaire). The patient's results were compared with their wives' results in order to determine trustworthiness. The goal of this study was to determine the factors influencing patient's critical assessment of their disease. The results reveal a relationship between patient's assessment and clinical manifestations of their dependence tend to underestimate the degree of their disease.
Assuntos
Alcoolismo/classificação , Autoavaliação (Psicologia) , Transtornos Relacionados ao Uso de Substâncias/classificação , Humanos , Masculino , CasamentoRESUMO
Effect of low body temperature on gastric secretory activity in the guinea pig under urethane general anaesthesia. Acta Physiol. Pol., 1978, 29 (1): 61-66. The effect of low body temperature on spontaneous and histamine (H) stimulated or Nalpha Nalpha-dimethylhistamine (NDMH)-stimulated gastric secretion was investigated in the guinea pig under general anaesthesia with urethane. In normothermia NDMH had a stronger stimulatory action on acid secretion In hypothermia (30 degrees C and 25 degrees C) only NDMH showed some stimulating effect. The obtained results point to the necessity of strict controlling of body temperature in the experiments performed on animals under general anaesthesia and suggest that the lack of effect at low temperature may be connected with an inhibition of the processes of H side-chain methylation when the rate of metabolic processes in the organism has fallen.
Assuntos
Temperatura Corporal , Mucosa Gástrica/metabolismo , Anestesia Geral , Animais , Feminino , Suco Gástrico/metabolismo , Mucosa Gástrica/efeitos dos fármacos , Cobaias , Histamina/farmacologia , Masculino , UretanaRESUMO
Influence of some inhibitors of histamine metabolism on the gastric secretion. Acta Physiol. Pol., 1977, 28 (6): 515-520. The influence of inhibitors of histamine metabolism on histamine (H) and Nalpha Nalpha-dimethylhistamine (NDMH) stimulated gastric secretion was studied in guinea-pigs and cats. Inhibitors of monoamine oxidase (MAO) and diamine oxidase (DAO): N-oxide diacetylaminopyridine (AAP) and N-oxide 2 aminopyridine (AP) increased HCI secretion in the gastric juice after H and NDMH. Inhibitors of N-methyl transferase: amodiaquine (A) and quinacrine (Q) increased HC1 secretion in the gastric juice after H but not after NDMH. The lack of action of A and Q on NDMH-stimulated gastric secretion suggests, that in guinea-pig and cat NDMH is not methylated additionally at the imidazole ring and therefore, it is a stronger gastric secretagogue than histamine itself.
