1.
Biotechnol J
; 3(9-10): 1147-56, 2008 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18624347
2.
J Nat Prod
; 68(9): 1397-9, 2005 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16180822
RESUMO
From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells.
