Assuntos
Flavonoides/farmacologia , Hipóxia/fisiopatologia , Potenciais de Ação/efeitos dos fármacos , Animais , Temperatura Corporal/efeitos dos fármacos , Interações Medicamentosas , Eletrocardiografia , Comportamento Exploratório/efeitos dos fármacos , Coração/efeitos dos fármacos , Técnicas In Vitro , Isoproterenol/farmacologia , Lactatos/sangue , Camundongos , Polímeros , Potássio/sangue , Coelhos , RatosRESUMO
During acute asphyxia in pentobarbital-narcotized cats, the elevation in plasma potassium level was parallel to that of PCO2. From the time when PO2 reached its minimum, the elevation in serum potassium was higher than that of plasma potassium. The increase of the difference between serum and plasma potassium values seems therefore to be more related to hypoxia than hypercapnia; it could be due to membrane alteration of blood cells.
Assuntos
Asfixia/sangue , Plasma/análise , Potássio/sangue , Animais , Dióxido de Carbono/sangue , Gatos , Lactatos/sangueRESUMO
When given orally in elevated but nonlethal doses (150 to 450 mg/kg, on 2 consecutive days), glafenine induces in rats (body weight 100 g) a transient nephritis with an increase in blood urea, hypertrophy of adrenals, and some changes in the serum proteinogram. These effects do not appear to be due to the 4-amino-7-chloroquinoline structure from which glafenine is derived, as they are not observed with the structural analogue chloroquine given at equimolar doses under the same conditions. Further, they do not appear to be due to glycerol, the by-product of metabolic glafenine hydrolysis. The responsible molecule appears to be either glafenine itself or its acid metabolite 4-(0-carboxyphenylamino) 7-chloroquinoline.
Assuntos
Cloroquina/farmacologia , Glafenina/farmacologia , ortoaminobenzoatos/farmacologia , Glândulas Suprarrenais/efeitos dos fármacos , Animais , Biotransformação , Coagulação Sanguínea/efeitos dos fármacos , Proteínas Sanguíneas/metabolismo , Peso Corporal/efeitos dos fármacos , Glafenina/metabolismo , Glicerol/farmacologia , Hematócrito , Masculino , Nefrite/induzido quimicamente , Tamanho do Órgão , Ratos , Relação Estrutura-Atividade , Ureia/sangueRESUMO
High doses of glafenine given orally to rats induced renal tubular changes and simultaneously raised not only blood urea concentrations but also adrenal volume and weight. These modifications were transient and dose-dependent. Blood urea and adrenal weight returned to normal at the same time. Treated rats showed no alteration in serum K+, Na+, Cl-, uric acid, glucose and cholesterol and only a slight decrease in serum transaminase levels. An indirect relationship between renal lesions and adrenals hypertrophy induced by flafenine may exist.
