[The diagnosis of micro- and macroangiopathies of the lesser circulation in diabetic patients]. / Diagnostika mikro- i makroangiopatii malogo kruga krovoobrashcheniia u bol'nykh sakharnym diabetom.

Patients with diabetes mellitus aged under 40 in the state of compensation demonstrate significant drop of pressure in the pulmonary artery system as compared to the corresponding parameter in those patients with diabetes mellitus beyond 40, which fact suggests presence of microangiopathies in the system of the pulmonary artery in the absence of concurrent pulmonary diseases and with similar duration of the illness.

[The myocardial contractile function and central hemodynamics of patients with insulin-dependent diabetes mellitus during treatment]. / Sokratitel'naia funktsiia miokarda i tsentral'naia gemodinamika u bol'nykh insulinzavisimym sakharnym diabetom v protsesse lecheniia.

The results of echocardiographic investigation of 48 patients with type I diabetes mellitus (DM) were compared: 48 patients received routine therapy including diabetic management, insulin and vitamin therapy, 32 received this type of therapy plus a complex consisting of inosine, benphothiamine and pyridoxal phosphate. A considerable decrease in myocardial contractility and hemodynamic disorder were revealed against a background of DM decompensation in both groups of patients. Clinical improvement resulting from the use of the above complex showed good correlation with a positive course of echocardiographic values of myocardial contractility and pumping function. Elimination of myocardial insufficiency was accompanied by an increase in the stroke volume, ejection fraction, the rate of circulatory shortening of myocardial fibers, left ventricular mass, and a decrease in end diastolic and systolic volumes. The second type of therapy was well tolerated by the patients and made it possible to considerably lessen myocardial insufficiency and reduce a period of treatment in hospital as compared to routine therapy.